2018
<i>Leishmania guyanensis</i> parasites block the activation of the inflammasome by inhibiting maturation of IL-1β
Hartley M, Eren R, Rossi M, Prevel F, Castiglioni P, Isorce N, Desponds C, Lye L, Beverley S, Drexler S, Fasel N. Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β. Microbial Cell 2018, 5: 137. PMID: 29487860, PMCID: PMC5826701, DOI: 10.15698/mic2018.03.619.Peer-Reviewed Original ResearchRIG-like receptorsInflammasome pathwayInnate pattern recognition receptorsPotent innate immunogenPattern recognition receptorsCytoplasmic dsRNA sensorsLesional inflammationTLR3 pathwaySymptomatic outcomeIL-1βInflammatory pathologyInflammatory responseInflammasome activationCutaneous leishmaniasisRecognition receptorsParasite burdenReceptor 3DsRNA sensorsVirus 1InfectionPathologyViral dsRNA genomeInflammasomeA20 proteinLRV1
2012
Leishmania RNA virus: when the host pays the toll
Hartley M, Ronet C, Zangger H, Beverley S, Fasel N. Leishmania RNA virus: when the host pays the toll. Frontiers In Cellular And Infection Microbiology 2012, 2: 99. PMID: 22919688, PMCID: PMC3417650, DOI: 10.3389/fcimb.2012.00099.Peer-Reviewed Original ResearchConceptsToll-like receptor 3Mucocutaneous leishmaniasisHyper-inflammatory immune responseLeishmania parasitesPotent innate immunogenExperimental animal modelsType 1 interferonLeishmania RNA virusAnti-leishmanial drugsMetastatic leishmaniasisDestructive inflammationMetastatic complicationsMetastatic diseaseInflammatory cascadeInflammatory stateRNA virusesSecondary lesionsImmune responseAnimal modelsClinical isolatesDisease severityReceptor 3Leishmania guyanensisMetastatic factorsClinical interventions