2018
<i>Leishmania guyanensis</i> parasites block the activation of the inflammasome by inhibiting maturation of IL-1β
Hartley M, Eren R, Rossi M, Prevel F, Castiglioni P, Isorce N, Desponds C, Lye L, Beverley S, Drexler S, Fasel N. Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β. Microbial Cell 2018, 5: 137. PMID: 29487860, PMCID: PMC5826701, DOI: 10.15698/mic2018.03.619.Peer-Reviewed Original ResearchRIG-like receptorsInflammasome pathwayInnate pattern recognition receptorsPotent innate immunogenPattern recognition receptorsCytoplasmic dsRNA sensorsLesional inflammationTLR3 pathwaySymptomatic outcomeIL-1βInflammatory pathologyInflammatory responseInflammasome activationCutaneous leishmaniasisRecognition receptorsParasite burdenReceptor 3DsRNA sensorsVirus 1InfectionPathologyViral dsRNA genomeInflammasomeA20 proteinLRV1
2017
Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid
Castiglioni P, Hartley M, Rossi M, Prevel F, Desponds C, Utzschneider D, Eren R, Zangger H, Brunner L, Collin N, Zehn D, Kuhlmann F, Beverley S, Fasel N, Ronet C. Exacerbated Leishmaniasis Caused by a Viral Endosymbiont can be Prevented by Immunization with Its Viral Capsid. PLOS Neglected Tropical Diseases 2017, 11: e0005240. PMID: 28099431, PMCID: PMC5242429, DOI: 10.1371/journal.pntd.0005240.Peer-Reviewed Original ResearchConceptsSymptomatic relapseVaccinated miceVaccine strategiesPotent innate immunogenSimilar viral infectionsVirus-related complicationsT-cell transferSpecific T cellsPoor treatment responseLesional inflammationSerum transferT helperInitial treatmentC57BL/6 miceNaïve miceLeishmania infectionPreventive benefitsVaccine opportunitiesT cellsTreatment responseImmune responseViral infectionLesion sizeClinical effortsLeishmania guyanensis