2022
Antiviral Treatment of Coronavirus Disease-2019 Pneumonia
Radcliffe C, Malinis M, Azar M. Antiviral Treatment of Coronavirus Disease-2019 Pneumonia. Clinics In Chest Medicine 2022, 44: 279-297. PMID: 37085220, PMCID: PMC9701636, DOI: 10.1016/j.ccm.2022.11.008.Peer-Reviewed Original ResearchConceptsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSyndrome coronavirus 2 infectionCoronavirus diseaseCoronavirus 2 infectionDirect acting antiviralsAdditional clinical trialsReal-world studyCOVID-19Acting antiviralsAntiviral treatmentTherapeutic optionsAvailable therapiesClinical trialsDisease progressionInpatient treatmentHigh riskEarly pandemicMonoclonal antibodiesDiseaseTreatmentMorbidityPandemicPneumoniaOutpatientsEvaluating clinical effectiveness of SARS‐CoV‐2 vaccine in solid organ transplant recipients: A propensity score matched analysis
Tucker M, Azar MM, Cohen E, Gan G, Deng Y, Palacios C, Malinis M. Evaluating clinical effectiveness of SARS‐CoV‐2 vaccine in solid organ transplant recipients: A propensity score matched analysis. Transplant Infectious Disease 2022, 24: e13876. PMID: 35684932, PMCID: PMC9348300, DOI: 10.1111/tid.13876.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsSARS-CoV-2 infectionOrgan transplant recipientsCritical COVID-19Clinical effectivenessTransplant recipientsVaccine eraVaccinated solid organ transplant recipientsCOVID-19Propensity score-matched cohortSARS-CoV-2 vaccinationSevere coronavirus disease 2019Cause-specific Cox regression modelsCOVID-19-related mortalitySARS-CoV-2 vaccinesSARS-CoV-2 infection ratesCurrent vaccine recommendationsKey preventative strategiesPrimary vaccine seriesRetrospective cohort studyDoses of mRNACox regression modelCoronavirus disease 2019Poisson regression modelsVaccine seriesDelayed Mortality Among Solid Organ Transplant Recipients Hospitalized for COVID-19
Heldman MR, Kates OS, Safa K, Kotton CN, Multani A, Georgia SJ, Steinbrink JM, Alexander BD, Blumberg EA, Haydel B, Hemmige V, Hemmersbach-Miller M, La Hoz RM, Moni L, Condor Y, Flores S, Munoz CG, Guitierrez J, Diaz EI, Diaz D, Vianna R, Guerra G, Loebe M, Yabu JM, Kramer KH, Tanna SD, Ison MG, Rakita RM, Malinis M, Azar MM, McCort ME, Singh PP, Velioglu A, Mehta SA, van Duin D, Goldman JD, Lease ED, Wald A, Limaye AP, Fisher CE, Besharatian B, Crespo M, Tomic R, Sehgal S, Weisshaar D, Girgis R, Lawrence C, Nelson J, Bennett W, Leandro J, Sait A, Rumore A, West P, Jeng A, Bajrovic V, Bilgili E, Anderson-Haag T, Nastase A, Badami A, Alvarez-Garcia J, Bowman-Anger L, Julien L, Ortiz-Bautista C, Friedman-Morocco R, Gajurel K, Cahuayme-Zuniga L, Wakefield M, Fung M, Theodoropoulos N, Chuang S, Bhandaram S, Veroux M, Chopra B, Florescu D, Witteck D, Diaz D, Ripley K, Saharia K, Akkina S, McCarty T, Webb A, Arya A, Vedula G, El-Amm J, Dokus M, Narayanan A, de Camargo P, Ouseph R, Breuckner A, Luk A, Aujayeb A, Ganger D, Keith D, Meloni F, Haidar G, Zapernick L, Morales M, Goyal N, Sharma T, Malhotra U, Kuo A, Rossi A, Edwards A, Keller B, Beneri C, Derringer D, Dominguez E, Carlson E, Hashim F, Murad H, Wilkens H, Neumann H, Gani I, Kahwaji J, Popoola J, Michaels M, Jakharia N, De la Cruz O, Puing A, Motallebzadeh R, Velagapudi R, Kapoor R, Allam S, Silveira F, Vora S, Kelly U, Reddy U, Dharnidharka V, Wadei H, Zurabi L. Delayed Mortality Among Solid Organ Transplant Recipients Hospitalized for COVID-19. Clinical Infectious Diseases 2022, 78: 711-718. PMID: 35212363, PMCID: PMC9383518, DOI: 10.1093/cid/ciac159.Peer-Reviewed Original ResearchSOT recipientsDay 28Day 90Multivariable Cox proportional hazards modelsSolid organ transplant recipientsCOVID-19Cox proportional hazards modelCOVID-19 focusOrgan transplant recipientsChronic lung diseaseBody mass indexProportional hazards modelSARS-CoV-2 detectionLung transplantMulticenter registryTransplant recipientsHeart failureMass indexIllness onsetVital statusLung diseaseRisk factorsDay 29Lower mortalityMortalityAn outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era
Roberts SC, Palacios C, Grubaugh ND, Alpert T, Ott IM, Breban MI, Initiative Y, Martinello RA, Smith C, Davis MW, Mcmanus D, Tirmizi S, Topal JE, Azar MM, Malinis M. An outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era. Transplant Infectious Disease 2022, 24: e13782. PMID: 34969164, DOI: 10.1111/tid.13782.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Infection prevention practicesSARS-CoV-2 outbreakTransplant unitCOVID-19-associated morbiditySolid organ transplant recipientsSARS-CoV-2 vaccinationPrevention practicesHospital day 18Potential index casesOrgan transplant recipientsInfection prevention behaviorsMonoclonal antibody therapyCOVID-19SARS-CoV-2 clustersHospital staff membersWhole-genome sequencingAsymptomatic patientsTransplant recipientsPositive patientsAtypical presentationImmunocompromised patientsAntibody therapyVaccination eraDisease progression
2021
Changing trends in mortality among solid organ transplant recipients hospitalized for COVID‐19 during the course of the pandemic
Heldman MR, Kates OS, Safa K, Kotton CN, Georgia SJ, Steinbrink JM, Alexander BD, Hemmersbach‐Miller M, Blumberg EA, Multani A, Haydel B, La Hoz RM, Moni L, Condor Y, Flores S, Munoz CG, Guitierrez J, Diaz EI, Diaz D, Vianna R, Guerra G, Loebe M, Rakita RM, Malinis M, Azar MM, Hemmige V, McCort ME, Chaudhry ZS, Singh PP, Kramer K, Velioglu A, Yabu JM, Morillis JA, Mehta SA, Tanna SD, Ison MG, Derenge AC, van Duin D, Maximin A, Gilbert C, Goldman JD, Lease ED, Fisher CE, Limaye AP, Team T. Changing trends in mortality among solid organ transplant recipients hospitalized for COVID‐19 during the course of the pandemic. American Journal Of Transplantation 2021, 22: 279-288. PMID: 34514710, PMCID: PMC8653312, DOI: 10.1111/ajt.16840.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsOrgan transplant recipientsTransplant recipientsCOVID-19IL-6/ILComorbidity-adjusted mortalityUse of corticosteroidsUse of hydroxychloroquineMultivariable logistic regressionBaseline comorbiditiesMulticenter registryImproved survivalReceptor inhibitorsGeneral populationMortality trendsMortalityLogistic regressionFurther studiesLater periodRecipientsCorticosteroidsComorbiditiesHydroxychloroquinePandemicPatientsCOVID‐19 in hospitalized lung and non‐lung solid organ transplant recipients: A comparative analysis from a multicenter study
Heldman MR, Kates OS, Safa K, Kotton CN, Georgia SJ, Steinbrink JM, Alexander BD, Hemmersbach‐Miller M, Blumberg EA, Crespo MM, Multani A, Lewis AV, Beaird O, Haydel B, La Hoz RM, Moni L, Condor Y, Flores S, Munoz CG, Guitierrez J, Diaz EI, Diaz D, Vianna R, Guerra G, Loebe M, Rakita RM, Malinis M, Azar MM, Hemmige V, McCort ME, Chaudhry ZS, Singh P, Hughes K, Velioglu A, Yabu JM, Morillis JA, Mehta SA, Tanna SD, Ison MG, Tomic R, Derenge A, van Duin D, Maximin A, Gilbert C, Goldman JD, Sehgal S, Weisshaar D, Girgis RE, Nelson J, Lease ED, Limaye AP, Fisher CE, Team T. COVID‐19 in hospitalized lung and non‐lung solid organ transplant recipients: A comparative analysis from a multicenter study. American Journal Of Transplantation 2021, 21: 2774-2784. PMID: 34008917, PMCID: PMC9215359, DOI: 10.1111/ajt.16692.Peer-Reviewed Original ResearchConceptsSolid organ transplant recipientsLung transplant recipientsOrgan transplant recipientsTransplant recipientsRisk factorsAllograft dysfunctionAdult solid organ transplant recipientsCOVID-19High mortalityChronic lung allograft dysfunctionOnly independent risk factorMultivariable logistic regression modelChronic allograft dysfunctionComorbidity-adjusted mortalityLung allograft dysfunctionMulticenter cohort studyIndependent risk factorCoronavirus disease 2019Logistic regression modelsLung transplantCohort studyHeart failureMulticenter studyDisease 2019MortalityA retrospective matched cohort single‐center study evaluating outcomes of COVID‐19 and the impact of immunomodulation on COVID‐19‐related cytokine release syndrome in solid organ transplant recipients
Ringer M, Azmy V, Kaman K, Tang D, Cheung H, Azar MM, Price C, Malinis M. A retrospective matched cohort single‐center study evaluating outcomes of COVID‐19 and the impact of immunomodulation on COVID‐19‐related cytokine release syndrome in solid organ transplant recipients. Transplant Infectious Disease 2021, 23: e13556. PMID: 33378571, PMCID: PMC7883059, DOI: 10.1111/tid.13556.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAntibodies, Monoclonal, HumanizedCase-Control StudiesCohort StudiesComorbidityCOVID-19COVID-19 Drug TreatmentCytokine Release SyndromeFemaleGlucocorticoidsGraft RejectionHeart TransplantationHospitalizationHumansImmunologic FactorsImmunosuppressive AgentsInterleukin-10Interleukin-6Kidney TransplantationLiver TransplantationMaleMiddle AgedReceptors, Interleukin-2Retrospective StudiesSARS-CoV-2Severity of Illness IndexTreatment OutcomeYoung AdultConceptsCytokine release syndromeBody mass indexNon-SOT patientsSOT groupSOT patientsRelease syndromeInterleukin-6COVID-19-related cytokine release syndromeSoluble interleukin-2 receptor levelsControl groupInterleukin-2 receptor levelsSolid organ transplant patientsSolid organ transplant recipientsImpact of immunomodulationInterleukin-10 levelsOrgan transplant recipientsOrgan transplant patientsCritical care needsMulti-center studyCoronavirus disease 2019COVID-19Interleukin levelsIndex hospitalizationTransplant patientsTransplant recipients
2020
Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome
Azar MM, Shin JJ, Kang I, Landry M. Diagnosis of SARS-CoV-2 infection in the setting of the cytokine release syndrome. Expert Review Of Molecular Diagnostics 2020, 20: 1087-1097. PMID: 32990479, DOI: 10.1080/14737159.2020.1830760.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Immune profileCOVID-19SARS-CoV-2 infectionCytokine release syndromeAdaptive immune cellsMultiple inflammatory cytokinesSARS-CoV-2 RNAFalse-negative resultsRelease syndromeInfectious complicationsIL-10Laboratory markersD-dimerInflammatory moleculesIP-10IL-6Inflammatory cytokinesMCP-1Acute diagnosisIL-2Immune cellsClinical severityTherapeutic benefitPathogenic contributionCoronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study
Kates OS, Haydel BM, Florman SS, Rana MM, Chaudhry ZS, Ramesh MS, Safa K, Kotton CN, Blumberg EA, Besharatian BD, Tanna SD, Ison MG, Malinis M, Azar MM, Rakita RM, Morilla JA, Majeed A, Sait AS, Spaggiari M, Hemmige V, Mehta SA, Neumann H, Badami A, Goldman JD, Lala A, Hemmersbach-Miller M, McCort ME, Bajrovic V, Ortiz-Bautista C, Friedman-Moraco R, Sehgal S, Lease ED, Fisher CE, Limaye AP, Arya A, Jeng A, Kuo A, Luk A, Puing A, Rossi A, Brueckner A, Multani A, Keller B, Derringer D, Florescu D, Dominguez E, Sandoval E, Bilgili E, Hashim F, Silveira F, Haidar G, Joharji H, Murad H, Gani I, el-amm J, Kahwaji J, Popoola J, Yabu J, Hughes K, Saharia K, Gajurel K, Bowman L, Veroux M, Morales M, Fung M, Theodoropoulos N, de la Cruz O, Kapoor R, La Hoz R, Allam S, Vora S, McCarty T, Anderson-Haag T, Malhotra U, Kelly U, Bhandaram V, Bennett W, Lominadze Z. Coronavirus Disease 2019 in Solid Organ Transplant: A Multicenter Cohort Study. Clinical Infectious Diseases 2020, 73: e4090-e4099. PMID: 32766815, PMCID: PMC7454362, DOI: 10.1093/cid/ciaa1097.Peer-Reviewed Original ResearchConceptsSOT recipientsUnderlying comorbiditiesCohort studyLaboratory-confirmed COVID-19Solid organ transplant recipientsMulti-center cohort studyCOVID-19Multicenter cohort studyOrgan transplant recipientsPredictors of mortalitySolid organ transplantsMultivariable logistic regressionKidney/pancreasCoronavirus disease 2019 (COVID-19) pandemicElectronic case report formCase report formsDisease 2019 pandemicImmunosuppression intensityStandardized intakePrimary endpointTransplant recipientsHospitalized patientsMedian ageTransplant centersClinical features