Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults
Azar MM, Schlaberg R, Malinis MF, Bermejo S, Schwarz T, Xie H, Dela Cruz CS. Added Diagnostic Utility of Clinical Metagenomics for the Diagnosis of Pneumonia in Immunocompromised Adults. CHEST Journal 2020, 159: 1356-1371. PMID: 33217418, DOI: 10.1016/j.chest.2020.11.008.Peer-Reviewed Original ResearchConceptsFinal clinical diagnosisDiagnostic yieldFungal pneumoniaImmunocompromised adultsMicrobiologic diagnosisAntimicrobial stewardshipMicrobiologic testingClinical diagnosisClinical metagenomicsCommunity-acquired pneumoniaStandard of careDiagnosis of pneumoniaAdult patientsRadiologic findingsBacterial pneumoniaBAL fluidProspective studyViral pneumoniaBacterial causePneumoniaDiagnostic utilityStudy designDiagnosisAdultsHypothetical impactGomori Methenamine Silver Stain on Bronchoalveolar Lavage Fluid Is Poorly Sensitive for Diagnosis of Pneumocystis jiroveci Pneumonia in HIV-Negative Immunocompromised Patients and May Lead to Missed or Delayed Diagnoses
Azar MM, Slotkin R, Abi-Raad R, Liu Y, Grant MH, Malinis MF. Gomori Methenamine Silver Stain on Bronchoalveolar Lavage Fluid Is Poorly Sensitive for Diagnosis of Pneumocystis jiroveci Pneumonia in HIV-Negative Immunocompromised Patients and May Lead to Missed or Delayed Diagnoses. Archives Of Pathology & Laboratory Medicine 2020, 144: 1003-1010. PMID: 31904277, DOI: 10.5858/arpa.2019-0394-oa.Peer-Reviewed Original ResearchHIV-negative immunocompromised patientsBronchoalveolar lavage fluidDiagnosis of PJPHIV-positive patientsImmunocompromised patientsLavage fluidGomori methenamine silver stainingPneumocystis jiroveci pneumoniaHIV-positive casesHuman immunodeficiency virusGomori methenamine silver stainMethenamine silver stainingMethenamine silver stainJiroveci pneumoniaBAL fluidHistorical gold standardRetrospective reviewImmunodeficiency virusPatientsLow burdenDiagnosisGMS stainGold standardPJPPneumonia