1993
A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells.
Schwartz M, Brown E, Fazeli B. A 50-kDa integrin-associated protein is required for integrin-regulated calcium entry in endothelial cells. Journal Of Biological Chemistry 1993, 268: 19931-19934. PMID: 8376355, DOI: 10.1016/s0021-9258(20)80675-9.Peer-Reviewed Original ResearchConceptsIntegrin-associated proteinExtracellular matrix proteinsMatrix proteinsEndothelial cellsIAP functionTransmembrane domainTyrosine phosphorylationPrimary sequenceEndothelial cell adhesionCell adhesionMembrane channelsProteinAnti-integrin antibodiesCalcium entryCellsIntracellular pHIon transportInflux of Ca2Activation of neutrophilsActivationCalcium channelsCalcium influxPhosphorylationNeutrophil functionMonoclonal antibodiesSpreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium.
Schwartz M. Spreading of human endothelial cells on fibronectin or vitronectin triggers elevation of intracellular free calcium. Journal Of Cell Biology 1993, 120: 1003-1010. PMID: 7679387, PMCID: PMC2200079, DOI: 10.1083/jcb.120.4.1003.Peer-Reviewed Original ResearchConceptsCalcium channelsBasal levelsVoltage-independent calcium channelsEndothelial cellsVoltage-dependent calcium channelsIntracellular free calciumElevation of pHiNa-Ca exchangerHuman endothelial cellsBeta 1 integrinIntracellular calciumFura-2Extracellular calciumFree calciumSubunit antibodiesSame antibodyIntracellular pHSteady-state levelsAntibodiesElevationCalciumCellsHigh steady-state levelsInvolvementIntegrins
1992
Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor.
Schwartz M, Lechene C. Adhesion is required for protein kinase C-dependent activation of the Na+/H+ antiporter by platelet-derived growth factor. Proceedings Of The National Academy Of Sciences Of The United States Of America 1992, 89: 6138-6141. PMID: 1378621, PMCID: PMC402137, DOI: 10.1073/pnas.89.13.6138.Peer-Reviewed Original ResearchMeSH KeywordsAcid-Base EquilibriumAnimalsCarrier ProteinsCell AdhesionCells, CulturedExtracellular MatrixHydrogen-Ion ConcentrationIn Vitro TechniquesMiceNaphthalenesPlatelet-Derived Growth FactorPolycyclic CompoundsProtein Kinase CSignal TransductionSodium-Hydrogen ExchangersTetradecanoylphorbol AcetateConceptsProtein kinase CPlatelet-derived growth factorKinase CAdherent cellsGrowth factorExtracellular matrix proteinsPKC-dependent pathwayElevation of intracellularMatrix proteinsAnchorage-dependent cellsCell adhesionDependent activationPKC activationAntiporterPhorbol esterSolid substratumPharmacological inhibitionC3H 10T1/2 cellsCellsActivationPathwayIntracellular pHAdhesionProteinIntegrins
1991
Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape.
Schwartz M, Lechene C, Ingber D. Insoluble fibronectin activates the Na/H antiporter by clustering and immobilizing integrin alpha 5 beta 1, independent of cell shape. Proceedings Of The National Academy Of Sciences Of The United States Of America 1991, 88: 7849-7853. PMID: 1652767, PMCID: PMC52401, DOI: 10.1073/pnas.88.17.7849.Peer-Reviewed Original ResearchMeSH KeywordsAmilorideAnimalsCarrier ProteinsCell AdhesionCell LineFibronectinsHumansHydrogen-Ion ConcentrationIntegrinsKineticsMiceMice, Inbred C3HSodium-Hydrogen ExchangersConceptsIntegrin alpha 5 beta 1Alpha 5 beta 1Cell shapeInsoluble extracellular matrix moleculesNa/H antiporterExtracellular matrix receptorsInsoluble fibronectinSurface-adsorbed fibronectinSoluble growth factorsExtracellular matrix moleculesH antiporterCell surface receptorsTransmembrane receptorsGrowth factor receptorBeta 1Matrix receptorsGrowth controlAnchorage-dependent cellsMatrix moleculesAntiporterFactor receptorSuppress growthSoluble mitogensGrowth factorFibronectinMultiple integrins share the ability to induce elevation of intracellular pH
Schwartz M, Ingber D, Lawrence M, Springer T, Lechene C. Multiple integrins share the ability to induce elevation of intracellular pH. Experimental Cell Research 1991, 195: 533-535. PMID: 1712734, DOI: 10.1016/0014-4827(91)90407-l.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCattleCell AdhesionCells, CulturedCollagenFibrinogenGlycoproteinsHumansHydrogen-Ion ConcentrationIntegrinsLamininMicrospheresVitronectinConceptsBovine capillary endothelial cellsElevation of pHiAlpha v beta 3Alpha 5 beta 1Capillary endothelial cellsElevation of intracellularT cell receptor complexIntegrin alpha v beta 3Human T lymphocytesPeripheral human T lymphocytesNa-H antiporterCollagen type IIICell receptor complexIntegrin familyT cellsT lymphocytesSignificant elevationIntegrin LFA-1Integrin alpha 5 beta 1LFA-1ICAM-2Endothelial cellsBeta 1Beta 3Antibodies
1990
Control of intracellular pH and growth by fibronectin in capillary endothelial cells.
Ingber D, Prusty D, Frangioni J, Cragoe E, Lechene C, Schwartz M. Control of intracellular pH and growth by fibronectin in capillary endothelial cells. Journal Of Cell Biology 1990, 110: 1803-1811. PMID: 2159481, PMCID: PMC2200182, DOI: 10.1083/jcb.110.5.1803.Peer-Reviewed Original ResearchpH regulation in spread cells and round cells.
Schwartz M, Cragoe E, Lechene C. pH regulation in spread cells and round cells. Journal Of Biological Chemistry 1990, 265: 1327-1332. PMID: 2153127, DOI: 10.1016/s0021-9258(19)40017-3.Peer-Reviewed Original ResearchMeSH KeywordsAmilorideBicarbonatesCarrier ProteinsCell AdhesionCell Physiological PhenomenaCellsChloridesHydrogen-Ion ConcentrationSodium-Hydrogen ExchangersCytoplasmic pH and anchorage-independent growth induced by v-Ki-ras, v-src or polyoma middle T.
Schwartz M, Rupp E, Frangioni J, Lechene C. Cytoplasmic pH and anchorage-independent growth induced by v-Ki-ras, v-src or polyoma middle T. Oncogene 1990, 5: 55-8. PMID: 2181378.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, Polyomavirus TransformingCell Transformation, NeoplasticCells, CulturedCytoplasmGenes, rasHydrogen-Ion ConcentrationOncogenesConceptsAnchorage-independent growthNormal cellsCytoplasmic pHPolyoma middle T oncogeneRas-transformed cellsCell linesExtracellular matrix proteinsMiddle T oncogeneV-SrcSrc oncogeneTissue culture plasticMatrix proteinsCellular requirementsCell growthControl growthOncogeneV-KiAlkaline pHiSeries of cellsCulture plasticGrowth factorCellsGrowthRAMutants
1989
Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts.
Schwartz M, Both G, Lechene C. Effect of cell spreading on cytoplasmic pH in normal and transformed fibroblasts. Proceedings Of The National Academy Of Sciences Of The United States Of America 1989, 86: 4525-4529. PMID: 2734302, PMCID: PMC287303, DOI: 10.1073/pnas.86.12.4525.Peer-Reviewed Original Research