2006
Matrix-specific Suppression of Integrin Activation in Shear Stress Signaling
Orr AW, Ginsberg MH, Shattil SJ, Deckmyn H, Schwartz MA. Matrix-specific Suppression of Integrin Activation in Shear Stress Signaling. Molecular Biology Of The Cell 2006, 17: 4686-4697. PMID: 16928957, PMCID: PMC1635406, DOI: 10.1091/mbc.e06-04-0289.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlood VesselsCattleCyclic AMP-Dependent Protein KinasesEndothelial CellsEnzyme ActivationExtracellular MatrixFibroblast Growth Factor 2FibronectinsIntegrin alpha2beta1Integrin alpha5beta1Integrin alphaVbeta3Models, BiologicalPhosphatidylinositol 3-KinasesPhosphatidylinositol PhosphatesProtein Kinase CSignal TransductionStress, MechanicalTalin
2005
The subendothelial extracellular matrix modulates NF-κB activation by flow
Orr AW, Sanders JM, Bevard M, Coleman E, Sarembock IJ, Schwartz MA. The subendothelial extracellular matrix modulates NF-κB activation by flow. Journal Of Cell Biology 2005, 169: 191-202. PMID: 15809308, PMCID: PMC2171897, DOI: 10.1083/jcb.200410073.Peer-Reviewed Original ResearchConceptsNF-kappaB activationSubendothelial extracellular matrixAtherosclerosis-prone sitesEarly monocyte recruitmentSigns of atherosclerosisFatty streak formationNovel therapeutic strategiesNF-κB activationSuppress NF-kappaB activationExtracellular matrixMonocyte recruitmentICAM-1VCAM-1Plaque formTherapeutic strategiesE-selectinP38-dependent pathwayNF-kappaBEndothelial cellsAtherosclerosisP38 activationNew integrinActivationStreak formationIntegrin alpha2beta1