2021
Vascular Mechanobiology: Homeostasis, Adaptation, and Disease
Humphrey JD, Schwartz MA. Vascular Mechanobiology: Homeostasis, Adaptation, and Disease. Annual Review Of Biomedical Engineering 2021, 23: 1-27. PMID: 34255994, PMCID: PMC8719655, DOI: 10.1146/annurev-bioeng-092419-060810.Peer-Reviewed Original ResearchConceptsArterial healthDisease progressionVascular wallTherapeutic needsHealthy vesselsHomeostatic mechanismsDiseaseVessel wallHomeostatic pathwaysPositive feedback loopWall mechanicsHomeostasisGene expressionOptimal functionMajor diseasesNegative feedback loopRegulatory pathwaysInflammationBiochemical meansArtery
2019
Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis
Chen PY, Qin L, Li G, Wang Z, Dahlman JE, Malagon-Lopez J, Gujja S, Cilfone N, Kauffman K, Sun L, Sun H, Zhang X, Aryal B, Canfran-Duque A, Liu R, Kusters P, Sehgal A, Jiao Y, Anderson D, Gulcher J, Fernandez-Hernando C, Lutgens E, Schwartz M, Pober J, Chittenden T, Tellides G, Simons M. Endothelial TGF-β signalling drives vascular inflammation and atherosclerosis. Nature Metabolism 2019, 1: 912-926. PMID: 31572976, PMCID: PMC6767930, DOI: 10.1038/s42255-019-0102-3.Peer-Reviewed Original ResearchConceptsTGF-β signalingVascular inflammationDisease progressionPlaque growthProgressive vascular diseaseVessel wall inflammationChronic inflammatory responseSpecific therapeutic interventionsAtherosclerotic plaque growthHyperlipidemic micePlaque inflammationWall inflammationProinflammatory effectsVascular diseaseInflammatory responseVascular permeabilityAtherosclerotic plaquesAbnormal shear stressTherapeutic interventionsInflammationEndothelial TGFΒ signalingVessel wallAtherosclerosisLipid retention