2004
p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility*
Stockton RA, Schaefer E, Schwartz MA. p21-activated Kinase Regulates Endothelial Permeability through Modulation of Contractility*. Journal Of Biological Chemistry 2004, 279: 46621-46630. PMID: 15333633, DOI: 10.1074/jbc.m408877200.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBlotting, WesternCattleCell CommunicationCells, CulturedCytokinesCytoskeletonEndothelium, VascularEnzyme ActivationHumansInflammationIschemiaMicroscopy, FluorescenceMuscle ContractionMyosin Light ChainsP21-Activated KinasesPeptidesPhosphorylationProtein Serine-Threonine KinasesProtein TransportThrombinTime FactorsTransfectionUmbilical VeinsConceptsP21-activated kinaseClose cell-cell associationsEndothelial cell-cell junctionsCell-cell junctionsActin stress fibersCell-cell associationsSuitable drug targetsGrowth factorMyosin phosphorylationHuman umbilical vein endothelial cellsCentral regulatorStress fibersUmbilical vein endothelial cellsEndothelial cellsPAK activationDrug targetsVein endothelial cellsCell contractilityMultiple growth factorsParacellular poresEndothelial permeabilityPhosphorylationPathological processesPathological conditionsPotential role
1993
The extracellular matrix as a cell survival factor.
Meredith J, Fazeli B, Schwartz M. The extracellular matrix as a cell survival factor. Molecular Biology Of The Cell 1993, 4: 953-961. PMID: 8257797, PMCID: PMC275725, DOI: 10.1091/mbc.4.9.953.Peer-Reviewed Original ResearchConceptsCell survival factorExtracellular matrixCell typesSurvival factorCell deathTyrosine phosphatase inhibitor sodium orthovanadateCell suicide pathwayRapid cell deathSuicide pathwayECM interactionsDNA degradationHuman endothelial cellsSodium orthovanadateCell growthPCDNucleus fragmentationTRPM-2Cell morphologyVascular cell adhesion molecule-1Class I histocompatibility antigenCell viabilityGrowth factorSpecific hormonesEndothelial cellsPotential role