2018
Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy
Liao X, Shen Y, Zhang R, Sugi K, Vasudevan NT, Alaiti MA, Sweet DR, Zhou L, Qing Y, Gerson SL, Fu C, Wynshaw-Boris A, Hu R, Schwartz MA, Fujioka H, Richardson B, Cameron MJ, Hayashi H, Stamler JS, Jain MK. Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy. Proceedings Of The National Academy Of Sciences Of The United States Of America 2018, 115: e4661-e4669. PMID: 29712858, PMCID: PMC5960298, DOI: 10.1073/pnas.1720065115.Peer-Reviewed Original ResearchConceptsNonischemic cardiomyopathyKruppel-like factor 4Resident macrophage proliferationNonresident macrophagesHeart failureCardiac functionMyeloid cellsBlood-borne macrophagesPreserves cardiac functionMacrophage proliferationPressure overload hypertrophyValvular diseaseOverload hypertrophyMyocardial angiogenesisAdaptive responseFirst weekMajor causeAngiogenic activityGenetic mutationsMacrophagesFactor 4CardiomyopathyKey transcription factorProliferationDistinct roles
2014
Chemokine-coupled β2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis
Morrison AR, Yarovinsky TO, Young BD, Moraes F, Ross TD, Ceneri N, Zhang J, Zhuang ZW, Sinusas AJ, Pardi R, Schwartz MA, Simons M, Bender JR. Chemokine-coupled β2 integrin–induced macrophage Rac2–Myosin IIA interaction regulates VEGF-A mRNA stability and arteriogenesis. Journal Of Experimental Medicine 2014, 211: 1957-1968. PMID: 25180062, PMCID: PMC4172219, DOI: 10.1084/jem.20132130.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsArteriesCD18 AntigensDNA PrimersFlow CytometryHumansMiceMice, Inbred C57BLMonocytesNeovascularization, PhysiologicNonmuscle Myosin Type IIARac GTP-Binding ProteinsReal-Time Polymerase Chain ReactionReceptors, CCR2RNA StabilityVascular Endothelial Growth Factor AX-Ray MicrotomographyConceptsMyosin IIASignal transduction eventsHuR translocationRapid nuclearTransduction eventsProteomic analysisProtein HuR.Induction of arteriogenesisMRNA stabilityMRNA stabilizationNovel roleCytosolic translocationMyosin-9ICAM-1 adhesionReceptor engagementDevelopmental vasculogenesisCellular effectorsMolecular triggersTranslocationHeavy chainGrowth factorMyeloid cellsVascular endothelial growth factorKey molecular triggerCCL2 stimulation