2021
Developmental Perspectives on Arterial Fate Specification
Chen D, Schwartz MA, Simons M. Developmental Perspectives on Arterial Fate Specification. Frontiers In Cell And Developmental Biology 2021, 9: 691335. PMID: 34249941, PMCID: PMC8269928, DOI: 10.3389/fcell.2021.691335.Peer-Reviewed Original ResearchVascular morphogenesisStress-induced cell cycle arrestPostnatal retinal angiogenesisKey molecular mechanismsArterial fateCell cycle arrestArterial specificationFate specificationVenous fateMolecular regulatorsMolecular mechanismsCycle arrestDorsal aortaMorphogenesisDevelopmental settingsRecent findings
2017
Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification
Fang JS, Coon BG, Gillis N, Chen Z, Qiu J, Chittenden TW, Burt JM, Schwartz MA, Hirschi KK. Shear-induced Notch-Cx37-p27 axis arrests endothelial cell cycle to enable arterial specification. Nature Communications 2017, 8: 2149. PMID: 29247167, PMCID: PMC5732288, DOI: 10.1038/s41467-017-01742-7.Peer-Reviewed Original ResearchConceptsEndothelial cell cycle arrestArterial gene expressionCell cycle arrestArterial specificationGene expressionCycle arrestArterial-venous specificationCell cycle inhibitor CDKN1BEndothelial cell cycleCell cycle inhibitionEmbryonic developmentBlood vessel formationP27 axisFunctional vascular networkCell cycleGrowth controlSpecialized phenotypeFluid shear stressCycle inhibitionVessel formationGrowth inhibitionTissue repairMechanochemical pathwayEndothelial cellsVascular regeneration