2010
Integrins and Extracellular Matrix in Mechanotransduction
Schwartz MA. Integrins and Extracellular Matrix in Mechanotransduction. Cold Spring Harbor Perspectives In Biology 2010, 2: a005066. PMID: 21084386, PMCID: PMC2982167, DOI: 10.1101/cshperspect.a005066.Peer-Reviewed Original ResearchConceptsIntegrin-mediated adhesionExtracellular matrixCytoskeletal linker proteinExtracellular matrix fibrilsIntracellular actin filamentsLinker proteinGenetic programActin filamentsExtracellular structuresCell survivalMatrix fibrilsIntegrinsCell functionCurrent knowledgeMechanotransductionMechanical forcesTransmits forcesIntracellularAdhesionCellsCytoskeletonProteinRegulationPathwayEnvironmental forcesRemembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor
Schwartz MA. Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor. Molecular Biology Of The Cell 2010, 21: 499-500. PMID: 20150528, PMCID: PMC2820415, DOI: 10.1091/mbc.e09-07-0602.Peer-Reviewed Original Research
2006
Regulation of Cell Adhesion Responses by Abl Family Kinases
Tanis K, Schwartz M. Regulation of Cell Adhesion Responses by Abl Family Kinases. Molecular Biology Intelligence Unit 2006, 16-25. DOI: 10.1007/978-0-387-68744-5_3.Peer-Reviewed Original ResearchAbl family kinasesFamily kinasesAbl familyMultiple focal adhesion proteinsFocal adhesion proteinsCytoskeletal regulatory proteinsNonreceptor tyrosine kinaseCell cycle progressionCell surface receptorsCell adhesive responsesInteraction of cellsIntegrin engagementRegulatory proteinsAdhesion proteinsGene expressionCell adhesion responsesCycle progressionCell spreadingTyrosine kinaseCellular responsesHuman diseasesCell survivalNuclear processesKinaseExtracellular matrix
2003
Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis
Hood JD, Frausto R, Kiosses WB, Schwartz MA, Cheresh DA. Differential αv integrin–mediated Ras-ERK signaling during two pathways of angiogenesis. Journal Of Cell Biology 2003, 162: 933-943. PMID: 12952943, PMCID: PMC2172815, DOI: 10.1083/jcb.200304105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsChick EmbryoEnzyme ActivationFibroblast Growth Factor 2Focal Adhesion Protein-Tyrosine KinasesIntegrin alphaVbeta3IntegrinsMitogen-Activated Protein KinasesNeovascularization, PhysiologicP21-Activated KinasesProtein Serine-Threonine KinasesProtein-Tyrosine KinasesProto-Oncogene Proteins c-rafRas ProteinsReceptors, VitronectinSignal TransductionSrc-Family KinasesVascular Endothelial Growth Factor AConceptsPathways of angiogenesisC-RafDistinct vascular responsesDownstream of RasUpstream of RasC-Raf activationC-Raf activityKinase-dependent phosphorylationRas-ERK pathwayInhibition of FAKVascular responsesPhosphorylation/activationSignal-related kinaseEndothelial cell survivalSerine 338Blood vesselsRas-ERKActive RAChick chorioallantoic membraneRA activityAngiogenesisERK activityRetroviral deliveryVEGFCell survival