1997
Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo.
Brooks P, Klemke R, Schon S, Lewis J, Schwartz M, Cheresh D. Insulin-like growth factor receptor cooperates with integrin alpha v beta 5 to promote tumor cell dissemination in vivo. Journal Of Clinical Investigation 1997, 99: 1390-1398. PMID: 9077549, PMCID: PMC507955, DOI: 10.1172/jci119298.Peer-Reviewed Original ResearchConceptsAlpha v beta 5Integrin alpha v beta 5Beta 5Growth factor-mediated signalsInsulin-like growth factor receptorSpontaneous pulmonary metastasesTumor cell metastasisMultiple tumor cell typesGrowth factor receptorIntegrin ligationCell motilityAdhesion proteinsTumor cell interactionsFunctional cooperationTumor cell growthCytokine receptorsTumor cell typesPulmonary metastasesCell typesCell metastasisCell growthMultiple tumor typesMetastatic cascadeTumor cellsFactor receptor
1996
Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation.
Lewis J, Cheresh D, Schwartz M. Protein kinase C regulates alpha v beta 5-dependent cytoskeletal associations and focal adhesion kinase phosphorylation. Journal Of Cell Biology 1996, 134: 1323-1332. PMID: 8794871, PMCID: PMC2120976, DOI: 10.1083/jcb.134.5.1323.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCell Adhesion MoleculesCricetinaeCytoskeletal ProteinsCytoskeletonEnzyme ActivationFocal Adhesion Kinase 1Focal Adhesion Protein-Tyrosine KinasesHumansIntegrinsMicroscopy, ConfocalPhosphorylationProtein Kinase CProtein-Tyrosine KinasesReceptors, VitronectinTumor Cells, CulturedVitronectinConceptsFocal adhesion kinaseAlpha v beta 5Protein kinase CAlpha v beta 3Phosphorylation of FAKActivation of PKCIntegrin alpha v beta 3Beta 3Kinase CBeta 5Focal adhesion proteinsFocal adhesion kinase phosphorylationAlpha vPKC inhibitor calphostin CTreatment of cellsCytoskeletal associationAdhesion kinaseTyrosine phosphorylationAdhesion proteinsCytoskeletal proteinsIntracellular proteinsCell spreadingKinase phosphorylationTalinTensin