2010
Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor
Schwartz MA. Remembrance of Dead Cells Past: Discovering That the Extracellular Matrix Is a Cell Survival Factor. Molecular Biology Of The Cell 2010, 21: 499-500. PMID: 20150528, PMCID: PMC2820415, DOI: 10.1091/mbc.e09-07-0602.Peer-Reviewed Original Research
2005
Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*
Katsumi A, Naoe T, Matsushita T, Kaibuchi K, Schwartz MA. Integrin Activation and Matrix Binding Mediate Cellular Responses to Mechanical Stretch*. Journal Of Biological Chemistry 2005, 280: 16546-16549. PMID: 15760908, DOI: 10.1074/jbc.c400455200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionEnzyme ActivationEnzyme InhibitorsExtracellular MatrixExtracellular Signal-Regulated MAP KinasesIntegrin alphaVbeta3IntegrinsJNK Mitogen-Activated Protein KinasesLigandsMAP Kinase Kinase 4MiceMitogen-Activated Protein Kinase KinasesNIH 3T3 CellsPhosphatidylinositol 3-KinasesPhosphorylationProtein ConformationSignal TransductionStress, MechanicalTime FactorsConceptsIntegrin activationExtracellular matrix proteinsRole of integrinsConformational activationBiochemical signalsNIH3T3 cellsMolecular mechanismsCellular responsesMatrix proteinsExtracellular matrixCell growthMechanical stretch stimulationIntegrin alphavbeta3IntegrinsMechanical tensionMechanical stretchCritical determinantStretch stimulationActivationPhosphoinositolMechanotransductionJNKProteinApoptosisDifferentiation
2002
Integrins regulate the apoptotic response to DNA damage through modulation of p53
Lewis JM, Truong TN, Schwartz MA. Integrins regulate the apoptotic response to DNA damage through modulation of p53. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 3627-3632. PMID: 11904424, PMCID: PMC122574, DOI: 10.1073/pnas.062698499.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodiesApoptosisCaspase 3CaspasesCell AdhesionCell SurvivalChromosome AberrationsCyclin-Dependent Kinase Inhibitor p16DNA DamageFibroblastsHumansIntegrinsMelanomaMiceMutationNuclear ProteinsOrgan SpecificityProto-Oncogene ProteinsProto-Oncogene Proteins c-mdm2Radiation, IonizingSarcomaTumor Cells, CulturedTumor Suppressor Protein p14ARFTumor Suppressor Protein p53ConceptsTumor cellsTherapy-resistant tumorsModulation of p53Susceptible tumor cellsDNA damageLevels of p53Low p53 levelsApoptosis of cellsTherapy resistanceAntiintegrin antibodiesCancer cellsP53 levelsSurvival of cellsP53Nonadherent cellsCell typesSurvivalApoptotic responseCellsP19 ARFApoptosisChromosomal instabilityFibroblastic cell typesDamageChemotherapy
2000
Death Effector Domain Protein PEA-15 Potentiates Ras Activation of Extracellular Signal Receptor-activated Kinase by an Adhesion-independent Mechanism
Ramos J, Hughes P, Renshaw M, Schwartz M, Formstecher E, Chneiweiss H, Ginsberg M. Death Effector Domain Protein PEA-15 Potentiates Ras Activation of Extracellular Signal Receptor-activated Kinase by an Adhesion-independent Mechanism. Molecular Biology Of The Cell 2000, 11: 2863-2872. PMID: 10982386, PMCID: PMC14961, DOI: 10.1091/mbc.11.9.2863.Peer-Reviewed Original ResearchMeSH Keywords3T3 CellsAnimalsApoptosis Regulatory ProteinsCell AdhesionCell LineCHO CellsCricetinaeEnzyme ActivationGuanosine TriphosphateHumansIntracellular Signaling Peptides and ProteinsJNK Mitogen-Activated Protein KinasesMAP Kinase Kinase Kinase 1MiceMitogen-Activated Protein KinasesP38 Mitogen-Activated Protein KinasesPhosphoproteinsProtein Serine-Threonine KinasesRas ProteinsRecombinant Fusion ProteinsSignal TransductionConceptsPEA-15 expressionPEA-15ERK activationMitogen-activated protein kinase kinaseMitogen-activated protein kinase pathwayAdhesion-independent mechanismsRas-dependent mannerProtein kinase kinaseRegulation of apoptosisProtein kinase pathwayChinese hamster ovary cellsRas guanosineKinase kinaseRas activationSignal receptorHamster ovary cellsH-RasKinase pathwayERK activityIntegrin activationERK signalingAnchorage dependenceOncogenic processesOvary cellsApoptosis
1997
Integrins, adhesion and apoptosis
Meredith J, Schwartz M. Integrins, adhesion and apoptosis. Trends In Cell Biology 1997, 7: 146-150. PMID: 17708932, DOI: 10.1016/s0962-8924(97)01002-7.Peer-Reviewed Original Research