Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury
Nowak-Machen M, Lange M, Exley M, Wu S, Usheva A, Robson SC. Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury. Purinergic Signalling 2015, 11: 455-461. PMID: 26306905, PMCID: PMC4648788, DOI: 10.1007/s11302-015-9463-6.Peer-Reviewed Original ResearchConceptsPulmonary NKT cellsHyperoxic lung injuryNKT cellsLung injuryBrP-LPALysophosphatidic acidLPA levelsNKT cell numbersNKT cell activationCell numberLPA antagonistsLPA generationIll patientsSerum levelsOrgan oxygenationMouse modelClinical practiceCell activationInjuryEctonucleotide pyrophosphatase/phosphodiesterase 2HyperoxiaToxic effectsVivoPhosphodiesterase 2Autotaxin