2017
Endothelial Notch signalling limits angiogenesis via control of artery formation
Hasan SS, Tsaryk R, Lange M, Wisniewski L, Moore JC, Lawson ND, Wojciechowska K, Schnittler H, Siekmann AF. Endothelial Notch signalling limits angiogenesis via control of artery formation. Nature Cell Biology 2017, 19: 928-940. PMID: 28714969, PMCID: PMC5534340, DOI: 10.1038/ncb3574.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedArteriesCell MovementCells, CulturedEndothelial CellsGene Expression Regulation, DevelopmentalGenotypeHomeodomain ProteinsHuman Umbilical Vein Endothelial CellsHumansIntracellular Signaling Peptides and ProteinsMembrane ProteinsMicroscopy, FluorescenceMicroscopy, VideoNeovascularization, PhysiologicNerve Tissue ProteinsPhenotypeReceptor, Notch1Receptors, CXCR4Signal TransductionTime FactorsTime-Lapse ImagingTransfectionZebrafishZebrafish ProteinsConceptsNotch signalingTip cellsBlood vessel growthChemokine receptor cxcr4aTip cell migrationArtery formationNotch ligand DLL4Role of NotchVessel growthStalk cellsNotch activationAngiogenic sproutingLigand DLL4Endothelial NotchCell migrationSignalingPlexus formationBlood flow patternsAngiogenesisArterial circulationCellsNotchExpressionCxcr4aZebrafish
2013
Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens
Lange M, Fujikawa T, Koulova A, Kang S, Griffin M, Lassaletta A, Erat A, Tobiash E, Bianchi C, Elmadhun N, Sellke F, Usheva A. Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens. Cell Cycle 2013, 13: 315-323. PMID: 24240190, PMCID: PMC3906247, DOI: 10.4161/cc.27056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCell ProliferationCoronary VesselsCulture Media, Serum-FreeCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p15Gene Knockdown TechniquesHumansMaleMammary ArteriesMitogensMyocytes, Smooth MusclePhosphorylationPrimary Cell CultureRetinoblastoma ProteinSerumSwineYY1 Transcription FactorConceptsCyclin-dependent kinase 2Internal mammary arteryCoronary artery SMCsDisease resistanceRb phosphorylationRetinoblastoma tumor suppressor proteinTumor suppressor proteinMammary arteryCoronary arteryCultured human cellsVascular smooth muscle cell responsesProtein speciesPhosphorylation profileSmooth muscle cell dedifferentiationSuppressor proteinPrevalence of restenosisKinase 2Serum stimulationMolecular mechanismsSmooth muscle cell responseMuscle cell dedifferentiationHuman cellsSMC populationCause of mortalitySiRNA knockdown