DNA breathing dynamics distinguish binding from nonbinding consensus sites for transcription factor YY1 in cells
Alexandrov BS, Fukuyo Y, Lange M, Horikoshi N, Gelev V, Rasmussen KØ, Bishop AR, Usheva A. DNA breathing dynamics distinguish binding from nonbinding consensus sites for transcription factor YY1 in cells. Nucleic Acids Research 2012, 40: 10116-10123. PMID: 22904068, PMCID: PMC3488223, DOI: 10.1093/nar/gks758.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceBinding SitesConsensus SequenceDNAHeLa CellsHumansMolecular Dynamics SimulationPlasminogenPolymorphism, Single NucleotidePromoter Regions, GeneticProtein BindingYY1 Transcription FactorConceptsTranscription factorsGenome-wide mappingProtein-DNA bindingGene expression regulatorsEssential biological processesTranscription factor YY1DNA binding sitesDNA breathing dynamicsGenomic functionsYY1 bindingFactor YY1Expression regulatorsPhenotypic diversityConsensus sitesSequence variationGel shiftBiological processesCellular behaviorSequence contextFunctional SNPsYY1Strand separationBreathing dynamicsDNA dynamicsBinding sites