2022
Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling
Lange M, Ohnesorge N, Hoffmann D, Rocha SF, Benedito R, Siekmann AF. Zebrafish mutants in vegfab can affect endothelial cell proliferation without altering ERK phosphorylation and are phenocopied by loss of PI3K signaling. Developmental Biology 2022, 486: 26-43. PMID: 35337795, PMCID: PMC11238767, DOI: 10.1016/j.ydbio.2022.03.006.Peer-Reviewed Original ResearchConceptsEndothelial cell migrationLong isoformPI3KCell migrationEC proliferationZebrafish trunkZebrafish mutantsMutant phenotypeCellular functionsIntersegmental blood vesselsMRNA splicingPI3-kinaseMAPK activationVegfabA PathwayERK phosphorylationExtracellular matrixEndothelial cell proliferationVEGFA isoformsIsoformsCell proliferationDistinct setsProliferationBlood vessel networkMutations
2013
Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens
Lange M, Fujikawa T, Koulova A, Kang S, Griffin M, Lassaletta A, Erat A, Tobiash E, Bianchi C, Elmadhun N, Sellke F, Usheva A. Arterial territory-specific phosphorylated retinoblastoma protein species and CDK2 promote differences in the vascular smooth muscle cell response to mitogens. Cell Cycle 2013, 13: 315-323. PMID: 24240190, PMCID: PMC3906247, DOI: 10.4161/cc.27056.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCell ProliferationCoronary VesselsCulture Media, Serum-FreeCyclin-Dependent Kinase 2Cyclin-Dependent Kinase 4Cyclin-Dependent Kinase Inhibitor p15Gene Knockdown TechniquesHumansMaleMammary ArteriesMitogensMyocytes, Smooth MusclePhosphorylationPrimary Cell CultureRetinoblastoma ProteinSerumSwineYY1 Transcription FactorConceptsCyclin-dependent kinase 2Internal mammary arteryCoronary artery SMCsDisease resistanceRb phosphorylationRetinoblastoma tumor suppressor proteinTumor suppressor proteinMammary arteryCoronary arteryCultured human cellsVascular smooth muscle cell responsesProtein speciesPhosphorylation profileSmooth muscle cell dedifferentiationSuppressor proteinPrevalence of restenosisKinase 2Serum stimulationMolecular mechanismsSmooth muscle cell responseMuscle cell dedifferentiationHuman cellsSMC populationCause of mortalitySiRNA knockdown