Featured Publications
Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity
Ruff WE, Dehner C, Kim WJ, Pagovich O, Aguiar CL, Yu AT, Roth AS, Vieira SM, Kriegel C, Adeniyi O, Mulla MJ, Abrahams VM, Kwok WW, Nussinov R, Erkan D, Goodman AL, Kriegel MA. Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity. Cell Host & Microbe 2019, 26: 100-113.e8. PMID: 31227334, PMCID: PMC8194364, DOI: 10.1016/j.chom.2019.05.003.Peer-Reviewed Original ResearchConceptsAntiphospholipid syndromePathogenic monoclonal antibodyHuman autoimmune diseasesGut commensalsB-cell autoepitopesHuman gut commensalGPI IgGAPS patientsIgG titersOral gavageMemory TSusceptible miceAntigenic loadAutoimmune diseasesAutoimmune pathologyTrigger autoimmunityHuman autoimmunityGlycoprotein IGPI autoantibodiesAutoimmunityMonoclonal antibodiesCell clonesCross reactMimotopesAutoantibodies
2021
Development of a New International Antiphospholipid Syndrome Classification Criteria Phase I/II Report: Generation and Reduction of Candidate Criteria
Barbhaiya M, Zuily S, Ahmadzadeh Y, Amigo M, Avcin T, Bertolaccini M, Branch D, Jesus G, Devreese K, Frances C, Garcia D, Guillemin F, Levine S, Levy R, Lockshin M, Ortel T, Seshan S, Tektonidou M, Wahl D, Willis R, Naden R, Costenbader K, Erkan D, Agmon‐Levin N, Aguilar C, Alba P, Alpan O, Ambrozic A, Amoura Z, Andrade D, Andrade L, Appenzeller S, Esen B, Atsumi T, Berkun Y, Cabral A, Canaud G, Cervera R, Chen P, Chighizola C, Cimaz R, Cohen H, Costedoat‐Chalumeau N, Crowther M, Cuadrado M, de Groot P, de Moerloose P, Derksen R, Diz‐Kucukkaya R, Dörner T, Fortin P, Giannakopoulos B, Gómez‐Puerta J, Gonzalez E, Inanc M, Kenet G, Khamashta M, Kriegel M, Krilis S, Laskin C, Massicotte P, McCarty G, Meroni P, Mikdashi J, Myones B, Pengo V, Petri M, Roubey R, Sammaritano L, Sanna G, Sciascia S, Signorelli F, Soybilgic A, Tincani A, Woller S, Yelnik C. Development of a New International Antiphospholipid Syndrome Classification Criteria Phase I/II Report: Generation and Reduction of Candidate Criteria. Arthritis Care & Research 2021, 73: 1490-1501. PMID: 33253499, PMCID: PMC8966711, DOI: 10.1002/acr.24520.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAntiphospholipid SyndromeConsensusDelphi TechniqueHumansPredictive Value of TestsRheumatologySeverity of Illness IndexConceptsAntiphospholipid syndromeAPS classificationPhase IAPS classification criteriaCandidate criteriaPhase IIClassification criteriaItem reduction techniquesAmerican CollegeNominal group techniqueDelphi exerciseMultidisciplinary initiativeLaboratory domainHigher likelihoodRheumatologyCase collectionSystematic literature reviewPhysician scientistsPresent studyEuropean AllianceAggregate scoreLiterature reviewConsensus-based approach
2014
Diet, microbiota and autoimmune diseases
Vieira S, Pagovich O, Kriegel M. Diet, microbiota and autoimmune diseases. Lupus 2014, 23: 518-526. PMID: 24763536, PMCID: PMC4009622, DOI: 10.1177/0961203313501401.Peer-Reviewed Original ResearchConceptsAutoimmune diseasesGut microbial communityGerm-free mouse modelDevelopment of autoimmunityDiet-derived metabolitesType 1 diabetesSeverity of diseaseLife-prolonging effectAdaptive immune systemAntiphospholipid syndromeAutoimmune modelSystemic lupusMultiple sclerosisGastrointestinal tractMurine modelMouse modelRodent modelsImmunomodulatory potentialCommensal bacteriaImmune systemCaloric restrictionGut microbiomeDietary changesLupusGut commensals