Featured Publications
A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity
Zegarra-Ruiz DF, Beidaq A, Iñiguez AJ, Di Ricco M, Vieira S, Ruff WE, Mubiru D, Fine RL, Sterpka J, Greiling TM, Dehner C, Kriegel MA. A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity. Cell Host & Microbe 2018, 25: 113-127.e6. PMID: 30581114, PMCID: PMC6377154, DOI: 10.1016/j.chom.2018.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmunityClostridiaceaeDendritic CellsDietDiet TherapyDisease Models, AnimalDNA, RibosomalFatty Acids, VolatileFecesFemaleGastrointestinal MicrobiomeGerm-Free LifeGlomerulonephritisHumansHypersensitivityInterferon Type IKidneyLactobacillusLimosilactobacillus reuteriLupus Erythematosus, SystemicMembrane GlycoproteinsMiceMice, Inbred C57BLRNA, Ribosomal, 16SStarchSurvival RateToll-Like Receptor 7ConceptsPlasmacytoid dendritic cellsSystemic lupus erythematosusInterferon pathwayToll-like receptor 7L. reuteri colonizationGut microbiota compositionDietary resistant starchShort-chain fatty acidsAutoimmune manifestationsDependent mouse modelSLE patientsOrgan involvementDendritic cellsLupus erythematosusReceptor 7Systemic autoimmunityHuman autoimmunityMouse modelGut microbiotaMetabolic diseasesMicrobiota compositionWestern lifestyleAutoimmunityDietary effectsBeneficial effects
2018
Prevention of systemic autoimmunity by dietary modulation of the gut microbiota
Ruiz D, El-Beidaq A, Iniguez A, di Ricco M, Mubiro D, Vieira S, Ruff W, Sterpka J, Kriegel M. Prevention of systemic autoimmunity by dietary modulation of the gut microbiota. The Journal Of Immunology 2018, 200: 54.1-54.1. DOI: 10.4049/jimmunol.200.supp.54.1.Peer-Reviewed Original ResearchSystemic lupus erythematosusType I interferonShort-chain fatty acidsI interferonB6 miceTg miceAutoimmune diseasesGut microbiotaHuman systemic lupus erythematosusDendritic cell accumulationImmune-microbiota interactionsPrototypical autoimmune diseaseOnset of diseaseAmeliorate autoimmunityLupus inductionLupus manifestationsKidney involvementLupus pathogenesisLupus erythematosusTLR7 agonistSystemic autoimmunityPeyer's patchesDietary modulationCell accumulationGut microbial community