Featured Publications
Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity
Ruff WE, Dehner C, Kim WJ, Pagovich O, Aguiar CL, Yu AT, Roth AS, Vieira SM, Kriegel C, Adeniyi O, Mulla MJ, Abrahams VM, Kwok WW, Nussinov R, Erkan D, Goodman AL, Kriegel MA. Pathogenic Autoreactive T and B Cells Cross-React with Mimotopes Expressed by a Common Human Gut Commensal to Trigger Autoimmunity. Cell Host & Microbe 2019, 26: 100-113.e8. PMID: 31227334, PMCID: PMC8194364, DOI: 10.1016/j.chom.2019.05.003.Peer-Reviewed Original ResearchConceptsAntiphospholipid syndromePathogenic monoclonal antibodyHuman autoimmune diseasesGut commensalsB-cell autoepitopesHuman gut commensalGPI IgGAPS patientsIgG titersOral gavageMemory TSusceptible miceAntigenic loadAutoimmune diseasesAutoimmune pathologyTrigger autoimmunityHuman autoimmunityGlycoprotein IGPI autoantibodiesAutoimmunityMonoclonal antibodiesCell clonesCross reactMimotopesAutoantibodies
2017
Spontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination
Vieira S, Hiltensperger M, Kumar V, Dehner C, Zegarra-Ruiz D, Ruff W, Khan N, Goodman A, Kriegel M. Spontaneous Translocation of a Gut Pathobiont Drives Autoimmunity that is Preventable by Intramuscular Vaccination. The Journal Of Immunology 2017, 198: 199.20-199.20. DOI: 10.4049/jimmunol.198.supp.199.20.Peer-Reviewed Original ResearchMesenteric lymph nodesGut microbiotaE. gallinarumGerm-free (GF) C57BL/6 miceAutoimmune hepatitis patientsInduction of autoantibodiesPathogenesis of autoimmunityNovel therapeutic avenuesTfh cellsDietary antigensIntramuscular vaccineIntramuscular vaccinationHepatitis patientsLymph nodesGut barrierHost-microbiota interactionsOral gavageC57BL/6 miceSystemic autoimmunityPortal veinTherapeutic avenuesAutoimmunitySingle antibioticLiver tissueMice