2012
Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells
Kriegel MA, Rathinam C, Flavell RA. Pancreatic islet expression of chemokine CCL2 suppresses autoimmune diabetes via tolerogenic CD11c+ CD11b+ dendritic cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2012, 109: 3457-3462. PMID: 22328150, PMCID: PMC3295274, DOI: 10.1073/pnas.1115308109.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmunityCD11b AntigenCD11c AntigenCD4-Positive T-LymphocytesCell CountChemokine CCL2Dendritic CellsDiabetes Mellitus, Type 1FemaleGene Expression RegulationInsulinIslets of LangerhansLymph NodesMiceMice, Inbred NODMice, TransgenicPromoter Regions, GeneticRatsRecombinant Fusion ProteinsSelf ToleranceConceptsDendritic cellsType 1 diabetesCell infiltrateDiabetes developmentT cellsChemokine CCL2/MCPElevated IL-10 secretionPancreatic isletsCCL2/CCR2 axisCD80/CD86 expressionTransgenic NOD miceVivo transfer systemDendritic cell biologyImmune cell infiltratesIL-10 secretionNonobese diabetic (NOD) miceCCL2/MCPRat insulin promoterUnexpected beneficial roleHypoactive phenotypeLow CD40NOD backgroundPancreatic lymphAutoimmune diabetesNOD mice
2011
Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice
Kriegel MA, Sefik E, Hill JA, Wu HJ, Benoist C, Mathis D. Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 11548-11553. PMID: 21709219, PMCID: PMC3136249, DOI: 10.1073/pnas.1108924108.Peer-Reviewed Original ResearchConceptsDiabetes protectionSFB colonizationSmall intestinal lamina propriaSystemic lymphoid tissuesExperimental autoimmune encephalomyelitisNonobese diabetic (NOD) miceT cell compartmentImmune system alterationsType 1 diabetesDifferent Th subsetsSegmented filamentous bacteriaHost physiological functionsNOD miceAutoimmune encephalomyelitisInflammatory arthritisTh17 cellsTh subsetsAutoimmune responseDiabetic miceLymphoid tissueSI-LPSpontaneous modelT cellsLamina propriaMouse model