Featured Publications
A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity
Zegarra-Ruiz DF, Beidaq A, Iñiguez AJ, Di Ricco M, Vieira S, Ruff WE, Mubiru D, Fine RL, Sterpka J, Greiling TM, Dehner C, Kriegel MA. A Diet-Sensitive Commensal Lactobacillus Strain Mediates TLR7-Dependent Systemic Autoimmunity. Cell Host & Microbe 2018, 25: 113-127.e6. PMID: 30581114, PMCID: PMC6377154, DOI: 10.1016/j.chom.2018.11.009.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmunityClostridiaceaeDendritic CellsDietDiet TherapyDisease Models, AnimalDNA, RibosomalFatty Acids, VolatileFecesFemaleGastrointestinal MicrobiomeGerm-Free LifeGlomerulonephritisHumansHypersensitivityInterferon Type IKidneyLactobacillusLimosilactobacillus reuteriLupus Erythematosus, SystemicMembrane GlycoproteinsMiceMice, Inbred C57BLRNA, Ribosomal, 16SStarchSurvival RateToll-Like Receptor 7ConceptsPlasmacytoid dendritic cellsSystemic lupus erythematosusInterferon pathwayToll-like receptor 7L. reuteri colonizationGut microbiota compositionDietary resistant starchShort-chain fatty acidsAutoimmune manifestationsDependent mouse modelSLE patientsOrgan involvementDendritic cellsLupus erythematosusReceptor 7Systemic autoimmunityHuman autoimmunityMouse modelGut microbiotaMetabolic diseasesMicrobiota compositionWestern lifestyleAutoimmunityDietary effectsBeneficial effects
2015
Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740)
Manfredo Vieira S, Ruff W, Hiltensperger M, Yu A, Goodman A, Kriegel M. Gut commensal dependence of autoreactivity and Th17 cells in systemic autoimmunity (MUC9P.740). The Journal Of Immunology 2015, 194: 205.4-205.4. DOI: 10.4049/jimmunol.194.supp.205.4.Peer-Reviewed Original ResearchAntiphospholipid syndromeSegmented filamentous bacteriaSystemic autoimmunityGut microbiotaAntiphospholipid antibody productionRegulatory IL-10Gut microbiota compositionAntigen-specific effectsBroad-spectrum antibioticsAnaerobic gut microbiotaTh17 cellsIL-17Infectious triggerPathogenic autoantibodiesPulmonary emboliIL-10IL-21Myocardial infarctionIL-1BSplenocyte proliferationAntibody productionMicrobiota compositionImmune systemAutoimmunityMicrobiota