2021
Chapter 25 Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome
Greiling T, Vieira S, Kriegel M. Chapter 25 Microbiota influences on systemic lupus erythematosus and Sjögren’s syndrome. 2021, 211-221. DOI: 10.1016/b978-0-12-814551-7.00025-8.Peer-Reviewed Original ResearchSystemic lupus erythematosusSjögren's syndromeLupus erythematosusSystemic autoimmunityAdaptive immune responsesPathogenesis of autoimmunityToll-like receptorsProne hostsBarrier organsImmune responseAdaptive immunityInnate triggersAnimal modelsMicrobiota influenceCommensal bacteriaSyndromeMucus membranesAutoimmunityHuman autoantigensErythematosusPathogenesisMicrobiotaLive bacteriaHost tissuesInflammation
2017
Autoantibody cross-reactivity with a microbial protein from a prevalent human gut commensal in antiphospholipid syndrome
ruff W, Roth A, Dehner C, Vieira S, Goodman A, Kriegel M. Autoantibody cross-reactivity with a microbial protein from a prevalent human gut commensal in antiphospholipid syndrome. The Journal Of Immunology 2017, 198: 58.4-58.4. DOI: 10.4049/jimmunol.198.supp.58.4.Peer-Reviewed Original ResearchAntiphospholipid syndromeAPS patientsGut commensalsBALB/cJ miceMajor B-cell epitopeGut commensal bacteriaAnti-B2GPI antibodiesB-cell epitopesInfectious triggerAutoantibody productionIgG autoantibodiesAntigenic sourceUnknown etiologyAutoantibody reactivityControl antibodyCell epitopesGut microbiotaCommensal bacteriaMajor autoantigenLow titersAutoantibodiesHuman stoolMonoclonal antibodiesVivo studiesPersistent stimulus
2014
Diet, microbiota and autoimmune diseases
Vieira S, Pagovich O, Kriegel M. Diet, microbiota and autoimmune diseases. Lupus 2014, 23: 518-526. PMID: 24763536, PMCID: PMC4009622, DOI: 10.1177/0961203313501401.Peer-Reviewed Original ResearchConceptsAutoimmune diseasesGut microbial communityGerm-free mouse modelDevelopment of autoimmunityDiet-derived metabolitesType 1 diabetesSeverity of diseaseLife-prolonging effectAdaptive immune systemAntiphospholipid syndromeAutoimmune modelSystemic lupusMultiple sclerosisGastrointestinal tractMurine modelMouse modelRodent modelsImmunomodulatory potentialCommensal bacteriaImmune systemCaloric restrictionGut microbiomeDietary changesLupusGut commensals