Autoantibody cross-reactivity with a microbial protein from a prevalent human gut commensal in antiphospholipid syndrome
ruff W, Roth A, Dehner C, Vieira S, Goodman A, Kriegel M. Autoantibody cross-reactivity with a microbial protein from a prevalent human gut commensal in antiphospholipid syndrome. The Journal Of Immunology 2017, 198: 58.4-58.4. DOI: 10.4049/jimmunol.198.supp.58.4.Peer-Reviewed Original ResearchAntiphospholipid syndromeAPS patientsGut commensalsBALB/cJ miceMajor B-cell epitopeGut commensal bacteriaAnti-B2GPI antibodiesB-cell epitopesInfectious triggerAutoantibody productionIgG autoantibodiesAntigenic sourceUnknown etiologyAutoantibody reactivityControl antibodyCell epitopesGut microbiotaCommensal bacteriaMajor autoantigenLow titersAutoantibodiesHuman stoolMonoclonal antibodiesVivo studiesPersistent stimulusAutoantigen‐specific T and B Cell Cross‐reactivity to a Gut Commensal in Antiphospholipid Syndrome
Dehner C, Ruff W, Vieira S, Goodman A, Kriegel M. Autoantigen‐specific T and B Cell Cross‐reactivity to a Gut Commensal in Antiphospholipid Syndrome. The FASEB Journal 2017, 31 DOI: 10.1096/fasebj.31.1_supplement.184.7.Peer-Reviewed Original ResearchBALB/c miceAdaptive immune systemAntiphospholipid syndromeB cellsC miceT cellsCell epitopesImmune systemPathogenic T cell epitopesTetramer-positive T cellsCD4 memory T cellsMemory T cellsTNF-α ILAdaptive immune responsesT cell clonesT cell epitopesDose-responsive mannerHuman commensal bacteriumB-cell epitopesEpitope-specific monoclonal antibodiesIL-21Patient PBMCsLymph nodesGPI antibodiesAntigenic challenge