Essential Role for Rac in Heregulin β1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4
Yang C, Liu Y, Lemmon MA, Kazanietz MG. Essential Role for Rac in Heregulin β1 Mitogenic Signaling: a Mechanism That Involves Epidermal Growth Factor Receptor and Is Independent of ErbB4. Molecular And Cellular Biology 2006, 26: 831-842. PMID: 16428439, PMCID: PMC1347034, DOI: 10.1128/mcb.26.3.831-842.2006.Peer-Reviewed Original ResearchMeSH KeywordsAntibodies, BlockingBreast NeoplasmsCell MovementCell ProliferationEnzyme ActivationErbB ReceptorsFemaleHumansNeoplasm ProteinsNeuregulin-1Phosphatidylinositol 3-KinasesPhosphoinositide-3 Kinase InhibitorsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktReceptor, ErbB-2Receptor, ErbB-3Receptor, ErbB-4RNA InterferenceSrc-Family KinasesTumor Cells, CulturedConceptsExtracellular signal-regulated kinaseHeregulin beta1RNA interferenceBreast cancer cellsCancer cellsActin cytoskeleton reorganizationDepletion of Rac1Activation of RacInactivation of RacTransactivation of EGFRSignal-regulated kinaseErbB receptor inhibitorsEpidermal growth factor receptorRho GTPasesMitogenic signalingRac activationRac GTPaseEpidermal growth factorGrowth factor receptorCytoskeleton reorganizationDownstream effectorsMitogenic activityCancer cell proliferationERK activationBreast cancer cell proliferationPalmitoylation of the EGFR Ligand Spitz by Rasp Increases Spitz Activity by Restricting Its Diffusion
Miura GI, Buglino J, Alvarado D, Lemmon MA, Resh MD, Treisman JE. Palmitoylation of the EGFR Ligand Spitz by Rasp Increases Spitz Activity by Restricting Its Diffusion. Developmental Cell 2006, 10: 167-176. PMID: 16459296, DOI: 10.1016/j.devcel.2005.11.017.Peer-Reviewed Original ResearchMeSH KeywordsAcyltransferasesAnimalsBase SequenceBiological Transport, ActiveCell LineCell MembraneCysteineDNADrosophilaDrosophila ProteinsEpidermal Growth FactorErbB ReceptorsFemaleGenes, InsectIn Vitro TechniquesLigandsMaleMembrane ProteinsModels, BiologicalMutagenesis, Site-DirectedMutationOvaryPalmitic AcidRecombinant ProteinsTransfectionWings, AnimalConceptsEpidermal growth factor receptorDrosophila epidermal growth factor receptorEGFR ligand SpitzPlasma membrane associationN-terminal cysteine residueLigand SpitzMembrane associationWnt familyDevelopmental functionsGrowth factor receptorCysteine residuesBiological functionsLipid modificationPalmitoylationIntracellular proteinsCultured cellsCell membraneFactor receptorSpitzReduced activityVivoTransmembraneHedgehogProteinActivity