2008
Ligand-induced ErbB receptor dimerization
Lemmon MA. Ligand-induced ErbB receptor dimerization. Experimental Cell Research 2008, 315: 638-648. PMID: 19038249, PMCID: PMC2667204, DOI: 10.1016/j.yexcr.2008.10.024.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDimerizationErbB ReceptorsHumansLigandsModels, MolecularOncogene Proteins v-erbBProtein BindingProtein Structure, TertiaryConceptsReceptor dimerizationEGF receptorCell surfaceStructural studiesReceptor tyrosine kinasesReceptor extracellular regionExtracellular regionSimple overexpressionImportant new insightsTyrosine kinaseIntact receptorCell transformationStructural predictionsWhole receptorErbB familyErbB receptorsEGF bindingNegative cooperativityMechanistic componentsKey mechanistic componentNew insightsDimerizationReceptorsHomodimerizationKinase
2000
Extracellular domains drive homo‐ but not hetero‐dimerization of erbB receptors
Ferguson K, Darling P, Mohan M, Macatee T, Lemmon M. Extracellular domains drive homo‐ but not hetero‐dimerization of erbB receptors. The EMBO Journal 2000, 19: 4632-4643. PMID: 10970856, PMCID: PMC302059, DOI: 10.1093/emboj/19.17.4632.Peer-Reviewed Original ResearchDimerizationEpidermal Growth FactorHumansOncogene Proteins v-erbBProtein BindingReceptor, ErbB-2Recombinant Proteins