2021
Phosphatidylserine binding directly regulates TIM-3 function
Smith CM, Li A, Krishnamurthy N, Lemmon MA. Phosphatidylserine binding directly regulates TIM-3 function. Biochemical Journal 2021, 478: 3331-3349. PMID: 34435619, PMCID: PMC8454703, DOI: 10.1042/bcj20210425.Peer-Reviewed Original ResearchConceptsTim-3T cell receptorTherapeutic targetCo-signaling receptorsTim-3 functionTim-3 ligandTim-3 signalingCo-inhibitory receptorsCo-stimulatory receptorsImmune modulation approachesIL-2 secretionPotential therapeutic targetNF-κB signalingImportant therapeutic targetPD-1Jurkat cellsCultured Jurkat cellsT cellsCell receptorTCR stimulationReceptorsImportance of phosphatidylserineDifferent studiesCellsSignaling
2005
Membrane activity of the phospholipase C-δ1 pleckstrin homology (PH) domain
Flesch FM, Yu JW, Lemmon MA, Burger KN. Membrane activity of the phospholipase C-δ1 pleckstrin homology (PH) domain. Biochemical Journal 2005, 389: 435-441. PMID: 15755258, PMCID: PMC1175121, DOI: 10.1042/bj20041721.Peer-Reviewed Original Research