2009
Characterization of Novel PtdIns(4,5)P2 Effector Domains
Moravcevic K, Lemmon M. Characterization of Novel PtdIns(4,5)P2 Effector Domains. The FASEB Journal 2009, 23: 873.6-873.6. DOI: 10.1096/fasebj.23.1_supplement.873.6.Peer-Reviewed Original ResearchEffector domainPrevious genome-wide studiesPhosphoinositide-binding proteinsKey cellular processesGenome-wide studiesDifferent protein domainsEffector proteinsCellular functionsCellular processesProtein domainsBiochemical approachesS. cerevisiaeBiochemical basisCellular activitiesCandidate novelDirect interactionProteinNew insightsDomainCerevisiaeMajor rolePhosphoinositideBiologyEffectorsDiversity
2008
Ligand-induced ErbB receptor dimerization
Lemmon MA. Ligand-induced ErbB receptor dimerization. Experimental Cell Research 2008, 315: 638-648. PMID: 19038249, PMCID: PMC2667204, DOI: 10.1016/j.yexcr.2008.10.024.Peer-Reviewed Original ResearchConceptsReceptor dimerizationEGF receptorCell surfaceStructural studiesReceptor tyrosine kinasesReceptor extracellular regionExtracellular regionSimple overexpressionImportant new insightsTyrosine kinaseIntact receptorCell transformationStructural predictionsWhole receptorErbB familyErbB receptorsEGF bindingNegative cooperativityMechanistic componentsKey mechanistic componentNew insightsDimerizationReceptorsHomodimerizationKinase
2007
Ligand-Induced Structural Transitions in ErbB Receptor Extracellular Domains
Dawson JP, Bu Z, Lemmon MA. Ligand-Induced Structural Transitions in ErbB Receptor Extracellular Domains. Structure 2007, 15: 942-954. PMID: 17697999, DOI: 10.1016/j.str.2007.06.013.Peer-Reviewed Original ResearchConceptsExtracellular regionDimerization siteLow-resolution molecular envelopeEpidermal growth factor receptor (EGFR) activationGrowth factor receptor activationAutoinhibitory intramolecular interactionMajor domain rearrangementsSmall-angle X-ray scatteringReceptor extracellular domainDomain rearrangementsEGF receptorExtracellular domainLigand bindingEGFR mutantsReceptor conformationMutantsMolecular envelopeExtended conformationNew insightsReceptor activationCrystallographic studiesConformationIntramolecular interactionsReceptorsX-ray scattering