2014
Putting together structures of epidermal growth factor receptors
Bessman NJ, Freed DM, Lemmon MA. Putting together structures of epidermal growth factor receptors. Current Opinion In Structural Biology 2014, 29: 95-101. PMID: 25460273, PMCID: PMC4268130, DOI: 10.1016/j.sbi.2014.10.002.Peer-Reviewed Original ResearchConceptsEpidermal growth factor receptorGrowth factor receptorIntact epidermal growth factor receptorChemical biology methodsNumerous crystal structuresFactor receptorTyrosine kinase domainVariety of inhibitorsKinase domainExtracellular regionMembrane environmentIntracellular regionBiology methodsIntact receptorReceptorsCancer therapyNext challengeCrystal structureMembraneActivationRegionInhibitorsDomain
2002
Mechanism of ErbB1 and ErbB2 Hetero-Oligomerization
Yu J, Lemmon M. Mechanism of ErbB1 and ErbB2 Hetero-Oligomerization. 2002 DOI: 10.21236/ada409630.Peer-Reviewed Original ResearchB cell linesErbB2 interactsBreast cancer therapyAbsence of IL2B cell proliferationIL2 receptor betaBreast cancerReceptor betaERBB2 overexpressionErbB receptor ligandsReceptor ligandsErbB2Cancer therapyValuable targetVivo systemGamma chainIntracellular domainMechanism of activationExtracellular domain