2016
Cyclosporine for Dry Eye Associated With Nivolumab
Nguyen AT, Elia M, Materin MA, Sznol M, Chow J. Cyclosporine for Dry Eye Associated With Nivolumab. Cornea 2016, 35: 399-401. PMID: 26771550, DOI: 10.1097/ico.0000000000000724.Peer-Reviewed Original ResearchConceptsDry eye diseaseMetastatic melanomaTopical cyclosporineCorneal perforationDry eyeEye diseaseSevere dry eye symptomsBilateral dry eyesDry Eye AssociatedOcular surface inflammationSevere dry eyeDry eye symptomsImprovement of symptomsNivolumab therapyIntensive regimenSurface inflammationEye symptomsMetastatic diseaseClinical outcomesAggressive lubricationRight eyeCase reportNivolumabOcular surfaceAntitumor effects
2002
Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma.
Toso JF, Gill VJ, Hwu P, Marincola FM, Restifo NP, Schwartzentruber DJ, Sherry RM, Topalian SL, Yang JC, Stock F, Freezer LJ, Morton KE, Seipp C, Haworth L, Mavroukakis S, White D, MacDonald S, Mao J, Sznol M, Rosenberg SA. Phase I study of the intravenous administration of attenuated Salmonella typhimurium to patients with metastatic melanoma. Journal Of Clinical Oncology 2002, 20: 142-52. PMID: 11773163, PMCID: PMC2064865, DOI: 10.1200/jco.2002.20.1.142.Peer-Reviewed Original ResearchConceptsDose-related toxicityMetastatic melanomaAntitumor effectsTumor colonizationMetastatic renal cell carcinomaTumor necrosis factor alphaPhase IPresent phase IMaximum-tolerated doseObjective tumor regressionIntravenous bolus infusionAttenuated Salmonella typhimuriumDose-related increaseElevated alkaline phosphataseNecrosis factor alphaRenal cell carcinomaSalmonella typhimuriumPersistent bacteremiaIL-12Proinflammatory cytokinesCell carcinomaIL-6Intravenous infusionBolus infusionTumor regression