The pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis.
Okolicsányi L, Venuti M, Strazzabosco M, Iemmolo R, Nassuato G, Orlando R, Lirussi F. The pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis. Physiology International 1984, 64: 393-400. PMID: 6099684.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralCimetidineDose-Response Relationship, DrugHalf-LifeHumansInjections, IntravenousKineticsLiver CirrhosisMaleMetabolic Clearance RateRanitidineConceptsCompensated liver cirrhosisLiver cirrhosisPlasma concentrationsUrinary recoveryOral administrationDoses of cimetidinePharmacokinetics of cimetidineHigher plasma concentrationsSame plasma concentrationIntravenous cimetidineCirrhotic patientsSingle dosesH2 receptorsOral routeNormal subjectsPharmacokinetic parametersAdministration routeCimetidineRanitidineCirrhosisPharmacokineticsDosesPatientsAdministration