Oral and intravenous pharmacokinetics of ranitidine in patients with liver cirrhosis.
Okolicsanyi L, Venuti M, Strazzabosco M, Orlando R, Nassuato G, Iemmolo R, Lirussi F, Muraca M, Pastorino A, Castelli G. Oral and intravenous pharmacokinetics of ranitidine in patients with liver cirrhosis. International Journal Of Clinical Pharmacology And Therapeutics 1984, 22: 329-32. PMID: 6086536.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAdultAgedBiological AvailabilityFemaleHumansInjections, IntravenousKineticsLiver CirrhosisMaleMiddle AgedRanitidineConceptsCompensated liver cirrhosisLiver cirrhosisPharmacokinetics of ranitidineCirrhotic patientsUrinary recoveryUnchanged drugHealthy controlsPlasma concentrationsIntravenous pharmacokineticsPharmacokinetic dataPatientsCirrhosisOral bioavailabilityRanitidinePharmacokineticsHigh-performance liquid chromatographyPerformance liquid chromatographyCirrhoticsLiquid chromatographyControlThe pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis.
Okolicsányi L, Venuti M, Strazzabosco M, Iemmolo R, Nassuato G, Orlando R, Lirussi F. The pharmacokinetics of H2 receptor blocking agents in compensated liver cirrhosis. Physiology International 1984, 64: 393-400. PMID: 6099684.Peer-Reviewed Original ResearchConceptsCompensated liver cirrhosisLiver cirrhosisPlasma concentrationsUrinary recoveryOral administrationDoses of cimetidinePharmacokinetics of cimetidineHigher plasma concentrationsSame plasma concentrationIntravenous cimetidineCirrhotic patientsSingle dosesH2 receptorsOral routeNormal subjectsPharmacokinetic parametersAdministration routeCimetidineRanitidineCirrhosisPharmacokineticsDosesPatientsAdministration