2015
Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation
Morton SD, Cadamuro M, Brivio S, Vismara M, Stecca T, Massani M, Bassi N, Furlanetto A, Joplin RE, Floreani A, Fabris L, Strazzabosco M. Leukemia inhibitory factor protects cholangiocarcinoma cells from drug-induced apoptosis via a PI3K/AKT-dependent Mcl-1 activation. Oncotarget 2015, 6: 26052-26064. PMID: 26296968, PMCID: PMC4694885, DOI: 10.18632/oncotarget.4482.Peer-Reviewed Original ResearchMeSH KeywordsAntineoplastic AgentsApoptosisBile Duct NeoplasmsBlotting, WesternCell Line, TumorCholangiocarcinomaCisplatinDeoxycytidineGemcitabineGene Expression Regulation, NeoplasticHumansLeukemia Inhibitory FactorLeukemia Inhibitory Factor Receptor alpha SubunitMicroscopy, FluorescenceMyeloid Cell Leukemia Sequence 1 ProteinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReverse Transcriptase Polymerase Chain ReactionRNA InterferenceSignal TransductionConceptsLeukemia inhibitory factorDrug-induced apoptosisChemotherapy-induced apoptosisPI3K inhibitionLIF effectsLIFR expressionExpression of LIFInhibitory factorRole of LIFCholangiocarcinoma cellsK inhibitionPI3K/Akt-dependent pathwayTumor stromal cellsHuman cholangiocarcinoma cell linesCell-like phenotypeCholangiocarcinoma cell linesMcl-1Akt-dependent pathwayUp-regulating Mcl-1IL-6 family cytokinesLIF secretionLiver malignanciesCholangiocarcinoma cell proliferationAnti-apoptotic proteinsFamily cytokines
1998
Functional polarity of Na+/H+and Cl−/ HCO 3 − exchangers in a rat cholangiocyte cell line
Spirlì C, Granato A, Zsembery A, Anglani F, Okolicsànyi L, LaRusso N, Crepaldi G, Strazzabosco M. Functional polarity of Na+/H+and Cl−/ HCO 3 − exchangers in a rat cholangiocyte cell line. American Journal Of Physiology 1998, 275: g1236-g1245. PMID: 9843758, DOI: 10.1152/ajpgi.1998.275.6.g1236.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntiportersBile DuctsCell LineCell PolarityChloride-Bicarbonate AntiportersGene ExpressionIsomerismRatsReverse Transcriptase Polymerase Chain ReactionSodium-Hydrogen ExchangersConceptsRat cholangiocyte cell lineCholangiocyte cell lineHOE 642Intrahepatic bile duct cellsCell linesNHE isoformsBile duct cellsAcid-base transportersPHi recoveryApical administrationBasolateral amilorideSeparate perfusionFirst functional descriptionAcid loadBasolateral aspectNHE3 gene expressionDuct cellsGene expressionRT-PCRApical amilorideElectrolyte transportAE2 mRNAAmilorideHCO-3Isoforms