2015
Malignancies in Primary Sclerosing Cholangitis - A Continuing Threat
Bonato G, Cristoferi L, Strazzabosco M, Fabris L. Malignancies in Primary Sclerosing Cholangitis - A Continuing Threat. Digestive Diseases 2015, 33: 140-148. PMID: 26641079, PMCID: PMC4939833, DOI: 10.1159/000440826.Peer-Reviewed Original ResearchMeSH KeywordsBile Duct NeoplasmsCholangiocarcinomaCholangitis, SclerosingColorectal NeoplasmsGallbladder NeoplasmsHumansInflammatory Bowel DiseasesNeoplasmsConceptsInflammatory bowel diseaseUlcerative colitisEffective medical treatmentGallbladder carcinomaColorectal carcinomaUnknown etiologyEarly diagnosisMedical treatmentChronic inflammatory liver diseaseManagement of PSCInflammatory liver diseasePrimary sclerosing cholangitisGroup of patientsChronic inflammatory conditionsChronic inflammatory diseaseBile duct systemRisk of cancerDevelopment of malignancyEffective surveillance strategiesExtensive histologicLiver transplantationNeoadjuvant chemoradiotherapySclerosing cholangitisFeared complicationFrequent complication
2010
Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C
Hov JR, Lleo A, Selmi C, Woldseth B, Fabris L, Strazzabosco M, Karlsen TH, Invernizzi P. Genetic associations in Italian primary sclerosing cholangitis: Heterogeneity across Europe defines a critical role for HLA-C. Journal Of Hepatology 2010, 52: 712-717. PMID: 20347497, DOI: 10.1016/j.jhep.2009.11.029.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCholangitis, SclerosingChromosome MappingChromosomes, Human, Pair 6EuropeFemaleGene FrequencyHLA-B AntigensHLA-C AntigensHLA-DR AntigensHLA-DRB1 ChainsHumansInflammatory Bowel DiseasesItalyLiver CirrhosisMaleMicrosatellite RepeatsMiddle AgedReference ValuesRisk AssessmentYoung AdultConceptsPrimary sclerosing cholangitisSclerosing cholangitisHLA-DRB1Risk of PSCTNF-alpha -308GNatural killer cellsP-valueChi-square testHLA-C2PSC patientsKiller cellsTumor necrosisPSC pathogenesisT lymphocytesSignificant associationAbstractTextMICA locusHLA complexHLADRB1CholangitisUncorrected p-valueKIRFurther studiesAIMS
2008
Incidence and Management of Colorectal Cancer in Liver Transplant Recipients
Nishihori T, Strazzabosco M, Saif MW. Incidence and Management of Colorectal Cancer in Liver Transplant Recipients. Clinical Colorectal Cancer 2008, 7: 260-266. PMID: 18650194, PMCID: PMC3755274, DOI: 10.3816/ccc.2008.n.033.Peer-Reviewed Original ResearchConceptsLiver transplant recipientsTransplant recipientsColorectal cancerLiver transplantationPatient populationColon cancerDe novo colorectal cancerDe novo malignanciesLong-term immunosuppressionMetastatic colorectal cancerPrimary sclerosing cholangitisInflammatory bowel diseaseMajor health concernChronic rejectionNovo malignanciesProlonged immunosuppressionSclerosing cholangitisPosttransplantation periodBiologic agentsBowel diseaseCombination chemotherapyProphylactic colectomyOverall incidenceCommon malignancyLymphoproliferative disease