2020
Introduction to the Physiology, Immunology and Pathology of the Liver and Biliary Tree
Carbone M, Strazzabosco M. Introduction to the Physiology, Immunology and Pathology of the Liver and Biliary Tree. 2020, 3-20. DOI: 10.1002/9781119532637.ch1.Peer-Reviewed Original ResearchBile acidsBile formationDietary lipid absorptionMetabolism of bilirubinBiliary tree stem cellsBiliary treeLiver synthesisHepatic metabolismLipid absorptionEnergy homeostasisCholesterol homeostasisMetabolic homeostasisLiverCanalicular secretionStem cellsSecretionHomeostasisRegenerative abilityMetabolismBilirubinPathologyEndotoxinImmunology
2018
Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation
Riva G, Cilibrasi C, Bazzoni R, Cadamuro M, Negroni C, Butta V, Strazzabosco M, Dalprà L, Lavitrano M, Bentivegna A. Valproic Acid Inhibits Proliferation and Reduces Invasiveness in Glioma Stem Cells Through Wnt/β Catenin Signalling Activation. Genes 2018, 9: 522. PMID: 30373123, PMCID: PMC6267016, DOI: 10.3390/genes9110522.Peer-Reviewed Original ResearchGSC proliferationMethylation changesBioinformatics analysisGenome-wide dataStem cellsWnt/β-catenin signalingCell-signaling pathwaysWnt/β-catenin signaling activationWnt/β-cateninValproic acidΒ-catenin signalingVPA effectsHistone deacetylase inhibitorsGlioma stem cellsTrypan blue assayReal-time PCRLuciferase reporterN-cadherinSignaling ActivationPleiotropic effectsAnti-cancer effectsΒ-cateninE-cadherinCommon malignant brain tumorGSC invasionLiver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases
Fiorotto R, Amenduni M, Mariotti V, Fabris L, Spirli C, Strazzabosco M. Liver diseases in the dish: iPSC and organoids as a new approach to modeling liver diseases. Biochimica Et Biophysica Acta (BBA) - Molecular Basis Of Disease 2018, 1865: 920-928. PMID: 30264693, PMCID: PMC6658095, DOI: 10.1016/j.bbadis.2018.08.038.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLiver diseaseStem cell fieldHepatocyte-like cellsPluripotent stem cellsRegenerative medicineNext-generation toolsSurvival of patientsRecent technological advancesMononuclear blood cellsPotential applicationsGene editingQuality of lifeLiver cell typesDisease modelingCell fieldAdequate cellular modelsLiver transplantationOrgan failureLiver specimensDiseaseStem cellsBlood cellsLiver cellsDrug testingSkin fibroblasts