Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggressiveness
Brivio S, Cadamuro M, Strazzabosco M, Fabris L. Tumor reactive stroma in cholangiocarcinoma: The fuel behind cancer aggressiveness. World Journal Of Hepatology 2017, 9: 455-468. PMID: 28396716, PMCID: PMC5368623, DOI: 10.4254/wjh.v9.i9.455.Peer-Reviewed Original ResearchTumor reactive stromaReactive stromaCCA progressionStromal cellsAggressive epithelial malignancyReactive stromal cellsProgression of cholangiocarcinomaEarly lymphDismal prognosisBiliary carcinogenesisCancer cell behaviorConventional chemotherapyBreast carcinomaDesmoplastic microenvironmentEpithelial malignanciesCancer aggressivenessCell aggressivenessNeoplastic cellsCholangiocarcinomaMetastatic disseminationCombinatorial therapySoluble factorsCancer typesParacrine communicationExtracellular matrix