2022
Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs
Mineur YS, Mose TN, Vanopdenbosch L, Etherington IM, Ogbejesi C, Islam A, Pineda CM, Crouse RB, Zhou W, Thompson DC, Bentham MP, Picciotto MR. Hippocampal acetylcholine modulates stress-related behaviors independent of specific cholinergic inputs. Molecular Psychiatry 2022, 27: 1829-1838. PMID: 34997190, PMCID: PMC9106825, DOI: 10.1038/s41380-021-01404-7.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholineAcetylcholinesteraseAnimalsCholine O-AcetyltransferaseCholinergic AgentsCholinergic NeuronsHippocampusHumansMiceConceptsStress-related behaviorsCholinergic inputMedial septum/diagonal bandBehavioral effectsBrain ACh levelsChAT-positive neuronsSelective chemogenetic activationMuscarinic ACh receptorsDepression-like symptomsSignificant behavioral effectsHippocampal acetylcholineMaladaptive behavioral responsesAntidepressant effectsCholinergic neuronsACh releaseChemogenetic activationChemogenetic inhibitionCholinergic antagonistsLocal infusionAcetylcholine levelsACh levelsDiagonal bandACh receptorsHippocampal neuronsPharmacological approaches
2014
GABAergic and glutamatergic efferents of the mouse ventral tegmental area
Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L, Picciotto MR. GABAergic and glutamatergic efferents of the mouse ventral tegmental area. The Journal Of Comparative Neurology 2014, 522: 3308-3334. PMID: 24715505, PMCID: PMC4107038, DOI: 10.1002/cne.23603.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CountCholine O-AcetyltransferaseDependovirusEfferent PathwaysGABAergic NeuronsGlutamate DecarboxylaseGlutamatesLuminescent ProteinsMiceMice, Inbred C57BLMice, TransgenicStilbamidinesSubstance PTyrosine 3-MonooxygenaseVentral Tegmental AreaVesicular Glutamate Transport Protein 2Vesicular Inhibitory Amino Acid Transport ProteinsConceptsVentral tegmental areaGABA neuronsVTA GABATegmental areaMouse ventral tegmental areaGABA projection neuronsVTA GABAergic neuronsVTA GABA neuronsMagnocellular preoptic nucleusDeep mesencephalic nucleusLocal inhibitory connectionsPrefrontal cortical regionsDrugs of abuseGlutamatergic efferentsSpecific anterogradeBrainstem targetsDorsal rapheNeurons projectGABAergic markersGABAergic neuronsRetrograde tracingProjection neuronsLateral hypothalamusMesencephalic nucleusCentral amygdala