2013
Differential Modulation of Brain Nicotinic Acetylcholine Receptor Function by Cytisine, Varenicline, and Two Novel Bispidine Compounds: Emergent Properties of a Hybrid Molecule
Peng C, Stokes C, Mineur YS, Picciotto MR, Tian C, Eibl C, Tomassoli I, Guendisch D, Papke RL. Differential Modulation of Brain Nicotinic Acetylcholine Receptor Function by Cytisine, Varenicline, and Two Novel Bispidine Compounds: Emergent Properties of a Hybrid Molecule. Journal Of Pharmacology And Experimental Therapeutics 2013, 347: 424-437. PMID: 23959137, PMCID: PMC3807070, DOI: 10.1124/jpet.113.206904.Peer-Reviewed Original ResearchMeSH KeywordsAlkaloidsAnimalsAzocinesBehavior, AnimalBenzazepinesBrainBridged Bicyclo Compounds, HeterocyclicDose-Response Relationship, DrugDrug Partial AgonismHEK293 CellsHumansMaleMembrane PotentialsMiceMolecular StructureNicotinic AgonistsOocytesPatch-Clamp TechniquesQuinolizinesQuinoxalinesRatsRats, Sprague-DawleyReceptors, NicotinicTobacco Use DisorderVareniclineXenopus laevisConceptsPartial agonistLGN neuronsMouse tail suspension testLateral geniculate nucleus neuronsNicotinic acetylcholine receptor functionPartial agonist therapiesTail suspension testStratum radiatum interneuronsSmoking cessation drugNicotinic partial agonistAcetylcholine receptor functionHuman embryonic kidney 293 cellsSteady-state activationAgonist therapyRadiatum interneuronsEmbryonic kidney 293 cellsCessation drugsNucleus neuronsSuspension testΑ7 currentsNicotine addictionSide effectsVareniclineΑ4β2 nAChRsSR interneurons
2010
Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis
Mineur YS, Picciotto MR. Nicotine receptors and depression: revisiting and revising the cholinergic hypothesis. Trends In Pharmacological Sciences 2010, 31: 580-586. PMID: 20965579, PMCID: PMC2991594, DOI: 10.1016/j.tips.2010.09.004.Peer-Reviewed Original ResearchConceptsEffects of nicotineDepressive symptomsNeuronal nAChRsNovel antidepressant medicationsDepression-like behaviorMajor depressive disorderNicotinic acetylcholine receptorsAntidepressant medicationNicotine receptorsCholinergic systemDepressive disorderCholinergic hypothesisPreclinical studiesNicotinic drugsPharmacological agentsNicotinic agentsAcetylcholine receptorsEndogenous neurotransmittersSymptomsNAChRsNicotineSmokingDepressed individualsAcetylcholineReceptorsThe Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative‐Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice
Kamens HM, Andersen J, Picciotto MR. The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative‐Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice. Alcohol Clinical And Experimental Research 2010, 34: 2053-2060. PMID: 20946306, PMCID: PMC2988947, DOI: 10.1111/j.1530-0277.2010.01301.x.Peer-Reviewed Original ResearchConceptsSedative-hypnotic effectsBaseline locomotor activityFixed-speed rotarodAlcohol abuseEthanol consumptionNicotinic acetylcholine receptor partial agonist vareniclineLocomotor activityEthanol-induced motor incoordinationAbility of vareniclineAcute ethanol injectionDuration of LORRLocomotor activity chambersEffects of vareniclineAcute ethanol administrationNew pharmacologic strategiesDowel testDuration of lossPartial agonist vareniclineEthanol-induced ataxiaBalance beamNicotinic modulationPharmacologic strategiesMotor incoordinationEthanol administrationSedative effects