2009
Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors
Picciotto MR, Brabant C, Einstein EB, Kamens HM, Neugebauer NM. Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors. Brain Research 2009, 1314: 206-218. PMID: 19699187, PMCID: PMC2819596, DOI: 10.1016/j.brainres.2009.08.033.Peer-Reviewed Original ResearchConceptsEffects of galaninStress-related behaviorsDrugs of abuseGalanin receptorsAbility of galaninPotential mechanismsAddiction-related disordersDrug-related behaviorsNumber of neuropeptidesGalanin effectsHPA axisMonoaminergic systemsDrug exposureTreatment of stressNeuronal activityGalaninBrain areasNeuronal functionBrain regionsAddictive drugsBrain circuitsNovel therapeuticsDrugsNeural activityReceptors
2008
Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice
Narasimhaiah R, Kamens HM, Picciotto MR. Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice. Psychopharmacology 2008, 204: 95-102. PMID: 19099295, PMCID: PMC2872184, DOI: 10.1007/s00213-008-1438-7.Peer-Reviewed Original ResearchConceptsVentral tegmental areaEffects of galaninNucleus accumbensNeuropeptide galaninPlace preferenceThreshold doseEffects of morphineMesolimbic dopamine systemMesolimbic dopaminergic pathwaySystemic cocaine injectionPlace preference paradigmCocaine-induced activationDrugs of abuseAmphetamine reinforcementWild-type controlsExtracellular signal-regulated kinase (ERK) activityTegmental areaCocaine injectionCocaine responseDopaminergic pathwaysConclusionsThese dataGalaninRewarding effectsDopamine systemDrug reinforcement
2006
Galanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase
Hawes JJ, Narasimhaiah R, Picciotto MR. Galanin and galanin‐like peptide modulate neurite outgrowth via protein kinase C‐mediated activation of extracellular signal‐related kinase. European Journal Of Neuroscience 2006, 23: 2937-2946. PMID: 16819983, DOI: 10.1111/j.1460-9568.2006.04828.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBlotting, WesternCell DifferentiationCells, CulturedDose-Response Relationship, DrugDrug InteractionsEmbryo, MammalianEnzyme ActivationEnzyme InhibitorsExtracellular Signal-Regulated MAP KinasesGalaninGalanin-Like PeptideNeuritesNeuronsProtein Kinase CRatsReceptors, GalaninReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStem CellsConceptsGalanin-like peptideProtein kinase CNervous systemNeurite outgrowthAdult hippocampal progenitor cellsAbility of galaninKinase CERK phosphorylationHippocampal progenitor cellsNeuronal cell line PC12Central nervous systemModulates Neurite OutgrowthExtracellular signal-related kinase (ERK) phosphorylationConcentration-dependent mannerNerve injuryNeuropeptide galaninNeurotrophic effectsExtracellular signal-related kinaseReceptor subtypesNovel physiological roleAdult brainGalaninCell line PC12Signal-related kinaseProgenitor cells
2004
Characterization of GalR1, GalR2, and GalR3 immunoreactivity in catecholaminergic nuclei of the mouse brain
Hawes JJ, Picciotto MR. Characterization of GalR1, GalR2, and GalR3 immunoreactivity in catecholaminergic nuclei of the mouse brain. The Journal Of Comparative Neurology 2004, 479: 410-423. PMID: 15514977, DOI: 10.1002/cne.20329.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCatecholaminesGalaninImmunohistochemistryLocus CoeruleusMiceNeural PathwaysNeuronsNucleus AccumbensOpioid-Related DisordersReceptor, Galanin, Type 1Receptor, Galanin, Type 2Receptor, Galanin, Type 3Receptors, GalaninRewardSubstantia NigraTyrosine 3-MonooxygenaseVentral Tegmental AreaConceptsVentral tegmental areaSubstantia nigraLocus coeruleusNucleus accumbensGalanin receptorsBrain areasMouse brainDistribution of immunoreactivityNoradrenergic transmissionGalanin bindingOpiate withdrawalTegmental areaCatecholaminergic nucleiTyrosine hydroxylaseDopamine neurotransmissionGalR1GalR2GalR3BrainProtein levelsDrug addictionGalaninImmunoreactivityReceptorsCoeruleus
2001
Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB‐dependent mechanism
Zachariou V, Georgescu D, Kansal L, Merriam P, Picciotto M. Galanin receptor 1 gene expression is regulated by cyclic AMP through a CREB‐dependent mechanism. Journal Of Neurochemistry 2001, 76: 191-200. PMID: 11145992, DOI: 10.1046/j.1471-4159.2001.00018.x.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBase SequenceCell LineCloning, MolecularCodon, InitiatorColforsinCyclic AMPCyclic AMP Response Element-Binding ProteinGene Expression RegulationMiceMolecular Sequence DataMutagenesis, Site-DirectedNerve Growth FactorNeuronsPromoter Regions, GeneticReceptors, GalaninReceptors, NeuropeptideRegulatory Sequences, Nucleic AcidSequence Homology, Nucleic AcidTetradecanoylphorbol AcetateTransfectionConceptsLocus coeruleusOpiate withdrawalGalanin binding sitesPeripheral nervous systemCREB-dependent mechanismG protein-coupled receptorsLevels of cAMPProtein-coupled receptorsOpiate analgesiaNeuropeptide galaninGalanin receptorsGalR1 mRNANervous systemPlace preferenceTranscription factor CREBForskolin effectGALR1 expressionGalR1 geneCAMP levelsCyclic AMPCell linesBasal activityCRE-like siteTransient transfection assaysReceptors
2000
Upregulation of Galanin Binding Sites and GalR1 mRNA Levels in the Mouse Locus Coeruleus Following Chronic Morphine Treatments and Precipitated Morphine Withdrawal
Zachariou V, Thome J, Parikh K, Picciotto M. Upregulation of Galanin Binding Sites and GalR1 mRNA Levels in the Mouse Locus Coeruleus Following Chronic Morphine Treatments and Precipitated Morphine Withdrawal. Neuropsychopharmacology 2000, 23: 127-137. PMID: 10882839, DOI: 10.1016/s0893-133x(00)00094-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBehavior, AnimalDrug Administration ScheduleFemaleGalaninIn Situ HybridizationIodine RadioisotopesLocus CoeruleusMiceMice, Inbred C57BLMorphineNaltrexoneNucleus AccumbensReceptors, GalaninReceptors, NeuropeptideRNA, MessengerSubstance Withdrawal SyndromeUp-RegulationVentral Tegmental AreaConceptsGalanin binding sitesLocus coeruleusMorphine treatmentMRNA levelsAcute morphine treatmentChronic morphine treatmentMouse locus coeruleusReceptor 1 geneLC neuronsMorphine administrationMorphine withdrawalNeuropeptide galaninOpiate withdrawalReceptor levelsBrain areasDrug dependenceGalaninCAMP levelsWithdrawalBinding sitesCoeruleusTreatmentLevelsGalR1Neurons
1999
Centrally administered galanin blocks morphine place preference in the mouse
Zachariou V, Parikh K, Picciotto M. Centrally administered galanin blocks morphine place preference in the mouse. Brain Research 1999, 831: 33-42. PMID: 10411981, DOI: 10.1016/s0006-8993(99)01476-6.Peer-Reviewed Original ResearchConceptsNucleus accumbensMorphine reinforcementLocus coeruleusSpinal cordPlace preferenceAcute naltrexone administrationGalanin binding sitesQuantitative receptor autoradiographyVentral tegmental areaMorphine place preferencePlace preference paradigmGalaninergic systemMorphine treatmentPeripheral administrationNaltrexone administrationReceptor autoradiographyGalanin bindingOpioid receptorsTegmental areaNeuroendocrine functionGalaninBrain areasDrug dependenceMorphineAversive properties