Brain Localization and Behavioral Impact of the G-Protein-Gated K+ Channel Subunit GIRK4
Wickman K, Karschin C, Karschin A, Picciotto M, Clapham D. Brain Localization and Behavioral Impact of the G-Protein-Gated K+ Channel Subunit GIRK4. Journal Of Neuroscience 2000, 20: 5608-5615. PMID: 10908597, PMCID: PMC6772558, DOI: 10.1523/jneurosci.20-15-05608.2000.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAvoidance LearningBehavior, AnimalBrain ChemistryChick EmbryoFemaleG Protein-Coupled Inwardly-Rectifying Potassium ChannelsGene ExpressionIn Situ HybridizationIon Channel GatingLocomotionMaleMaze LearningMemoryMiceMice, Inbred C57BLMice, KnockoutPotassium ChannelsPotassium Channels, Inwardly RectifyingRNA, MessengerConceptsGIRK4 mRNAG-protein-gated potassium (GIRK) channelsCortical pyramidal neuronsVentromedial hypothalamic nucleusParaventricular thalamic nucleusMorris water mazeG-Protein-GatedPassive avoidance paradigmMammalian nervous systemWild-type controlsEndopiriform nucleusPyramidal neuronsGlobus pallidusSynaptic inhibitionBrainstem nucleiHypothalamic nucleiPain perceptionThalamic nucleiInsular cortexNervous systemNeuronal populationsWater mazeLocomotor activityMouse brainGIRK subunitsUpregulation of Galanin Binding Sites and GalR1 mRNA Levels in the Mouse Locus Coeruleus Following Chronic Morphine Treatments and Precipitated Morphine Withdrawal
Zachariou V, Thome J, Parikh K, Picciotto M. Upregulation of Galanin Binding Sites and GalR1 mRNA Levels in the Mouse Locus Coeruleus Following Chronic Morphine Treatments and Precipitated Morphine Withdrawal. Neuropsychopharmacology 2000, 23: 127-137. PMID: 10882839, DOI: 10.1016/s0893-133x(00)00094-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoradiographyBehavior, AnimalDrug Administration ScheduleFemaleGalaninIn Situ HybridizationIodine RadioisotopesLocus CoeruleusMiceMice, Inbred C57BLMorphineNaltrexoneNucleus AccumbensReceptors, GalaninReceptors, NeuropeptideRNA, MessengerSubstance Withdrawal SyndromeUp-RegulationVentral Tegmental AreaConceptsGalanin binding sitesLocus coeruleusMorphine treatmentMRNA levelsAcute morphine treatmentChronic morphine treatmentMouse locus coeruleusReceptor 1 geneLC neuronsMorphine administrationMorphine withdrawalNeuropeptide galaninOpiate withdrawalReceptor levelsBrain areasDrug dependenceGalaninCAMP levelsWithdrawalBinding sitesCoeruleusTreatmentLevelsGalR1Neurons