2008
Molecular Mechanisms Underlying the Motivational Effects of Nicotine
Brunzell DH, Picciotto MR. Molecular Mechanisms Underlying the Motivational Effects of Nicotine. Nebraska Symposium On Motivation 2008, 55: 17-30. PMID: 19013937, PMCID: PMC3594851, DOI: 10.1007/978-0-387-78748-0_3.Peer-Reviewed Original Research
2006
The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo
Miwa JM, Stevens TR, King SL, Caldarone BJ, Ibanez-Tallon I, Xiao C, Fitzsimonds RM, Pavlides C, Lester HA, Picciotto MR, Heintz N. The Prototoxin lynx1 Acts on Nicotinic Acetylcholine Receptors to Balance Neuronal Activity and Survival In Vivo. Neuron 2006, 51: 587-600. PMID: 16950157, DOI: 10.1016/j.neuron.2006.07.025.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAge FactorsAnimalsAssociation LearningBrainCell SurvivalExcitatory Amino Acid AgonistsMembrane GlycoproteinsMembrane PotentialsMiceMice, Mutant StrainsMutationNerve DegenerationNeuronsNeuropeptidesNicotineNicotinic AgonistsPatch-Clamp TechniquesReceptors, NicotinicConceptsNicotinic acetylcholine receptorsNull mutant miceMutant miceAcetylcholine receptorsNeuronal activityNull mutationBiological processesLynx1Calcium levelsAgonist sensitivityReceptor desensitizationSynaptic efficacyMutationsAllosteric modulatorsDesensitization kineticsWide arrayNicotineVivoSpecific testsNAChRsMiceReceptorsSurvivalHyperactivationFunction
2005
β2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice
Brunzell DH, Chang JR, Schneider B, Olausson P, Taylor JR, Picciotto MR. β2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice. Psychopharmacology 2005, 184: 328-338. PMID: 16133126, DOI: 10.1007/s00213-005-0099-z.Peer-Reviewed Original ResearchConceptsNicotine exposureNicotinic acetylcholine receptorsFood-reinforced respondingAcetylcholine receptorsPrior nicotine exposureNicotine-induced increasesProgressive ratioNicotinic receptor subtypesEffects of nicotineWild-type miceProgressive ratio testC57BL/6 miceReceptor subtypesConclusionThese dataChronic exposureReinforcement testingMiceΒ2 subunitUnpaired presentationsExposureReceptorsApproach trainingPresentationPaired presentationsPrimary reinforcement