2006
Nicotine‐Mediated Activation of Signal Transduction Pathways
Picciotto M. Nicotine‐Mediated Activation of Signal Transduction Pathways. Novartis Foundation Symposia 2006, 275: 83-95. DOI: 10.1002/9780470029237.ch7.ChaptersCyclic AMP response element binding proteinSignal transductionProtein phosphatase calcineurinSignal transduction pathwaysMAP kinase pathwayActivation of proteinsResponse element-binding proteinElement-binding proteinTranscription factorsPhosphatase calcineurinTransduction pathwaysProtein kinaseKinase pathwayNicotinic acetylcholine receptorsBinding proteinProteinTransductionAcetylcholine receptorsPathwayCalcium entryActivationLong-term changesSynaptic strengthCircuit-level changesKinase
2001
Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications
Picciotto M, Caldarone B, Brunzell D, Zachariou V, Stevens T, King S. Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacology & Therapeutics 2001, 92: 89-108. PMID: 11916531, DOI: 10.1016/s0163-7258(01)00161-9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSignal transduction pathwaysHomologous recombinationTransduction pathwaysGenetic manipulationMolecular basisBehavioral phenotypesInactivation of nAChRsNicotinic acetylcholine receptorsSubunit compositionSubunitsNeuronal nicotinic receptorsPersistent activationNeurotransmitter releaseRelevant mutationsModel systemPossible clinical implicationsPhysiological propertiesAcetylcholine receptorsPhenotypeAutonomic gangliaNicotinic receptorsDisease statesDrug developmentPharmacological actionsNAChRs