2012
Imaging Changes in Synaptic Acetylcholine Availability in Living Human Subjects
Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP. Imaging Changes in Synaptic Acetylcholine Availability in Living Human Subjects. Journal Of Nuclear Medicine 2012, 54: 78-82. PMID: 23160789, PMCID: PMC3703589, DOI: 10.2967/jnumed.112.111922.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptor availabilityEndogenous neurotransmitter acetylcholineNicotinic acetylcholine receptorsPhysostigmine administrationAcetylcholine availabilityExtracellular acetylcholineBaseline scanHealthy subjectsReceptor availabilityExtracellular levelsAcetylcholine receptorsMolecular neuroimagingSPECT studiesAcetylcholineNonhuman primatesTissue concentrationsNeurotransmitter acetylcholineHuman subjectsSignificant reductionAdditional scansScansParent concentrationsSubjectsVivo estimationIA
2010
Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler
Esterlis I, Mitsis EM, Batis JC, Bois F, Picciotto MR, Stiklus SM, Kloczynski T, Perry E, Seibyl JP, McKee S, Staley JK, Cosgrove KP. Brain β2*-nicotinic acetylcholine receptor occupancy after use of a nicotine inhaler. The International Journal Of Neuropsychopharmacology 2010, 14: 389-398. PMID: 21029513, PMCID: PMC3510008, DOI: 10.1017/s1461145710001227.Peer-Reviewed Original ResearchConceptsNicotine inhalerWithdrawal symptomsReceptor occupancyTobacco smokingLow nicotine cigarettesAdministration of nicotineHigh receptor occupancyDoses of nicotineNicotinic acetylcholine receptorsInhaler useTobacco smokersBaseline scanRegular cigarettesInhalerConstant infusionAcetylcholine receptorsSPECT studiesCigarettesSymptomsBeta 2Significant decreaseNicotineSignificant differencesSmokingNAChRs