2021
Convergent Experimental Systems for Dissecting the Neurobiology of Intrusive Thought: A Road Map
Gourley S, Bonci A, Bruchas M, Flagel S, Haber S, Kalivas P, Milton A, Phillips P, Picciotto M, Seamans J. Convergent Experimental Systems for Dissecting the Neurobiology of Intrusive Thought: A Road Map. 2021, 53-76. DOI: 10.7551/mitpress/13875.003.0010.Peer-Reviewed Original ResearchIntrusive thoughtsIntrusive thinkingThought intrusionsKarl FristonMaladaptive behaviorsMost psychiatric disordersBehavioral processesSuch thoughtsUnacceptable behaviorBehavioral mechanismsW. RobbinsFuture researchRecurrent thoughtsDecision makingA. HolmesPsychiatric disordersThoughtFree willC. RobertsThinkingIndividual responsibilityPsychologyFotopoulouBanichNeuroscience
2015
Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states
Picciotto MR, Lewis AS, van Schalkwyk GI, Mineur YS. Mood and anxiety regulation by nicotinic acetylcholine receptors: A potential pathway to modulate aggression and related behavioral states. Neuropharmacology 2015, 96: 235-243. PMID: 25582289, PMCID: PMC4486625, DOI: 10.1016/j.neuropharm.2014.12.028.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptorsNicotinic medicationsAcetylcholine receptorsNicotinic agentsRole of nAChRsEffects of nicotineBehavioral statesSelf-medicate symptomsNicotinic effectsClinical trialsClinical studiesMood disordersPsychiatric disordersAnimal modelsAffective disordersMedicationsTobacco productsAnxiety regulationRelated constructsMental statesReceptorsDisordersNAChRsNicotineMood
2007
Deficiency in Inhibitory Cortical Interneurons Associates with Hyperactivity in Fibroblast Growth Factor Receptor 1 Mutant Mice
Smith K, Fagel DM, Stevens HE, Rabenstein RL, Maragnoli ME, Ohkubo Y, Picciotto MR, Schwartz ML, Vaccarino FM. Deficiency in Inhibitory Cortical Interneurons Associates with Hyperactivity in Fibroblast Growth Factor Receptor 1 Mutant Mice. Biological Psychiatry 2007, 63: 953-962. PMID: 17988653, DOI: 10.1016/j.biopsych.2007.09.020.Peer-Reviewed Original ResearchMeSH KeywordsAmphetamineAnimalsBehavior, AnimalBiogenic MonoaminesCell CountCentral Nervous System StimulantsCerebral CortexDisease Models, AnimalDopamine AgentsExploratory BehaviorFibroblast Growth Factor 1Glutamate DecarboxylaseHyperkinesisLocomotionMaleMethylphenidateMiceMice, KnockoutMotor ActivityNerve Tissue ProteinsNeural InhibitionNeuronsSignal TransductionConceptsInhibitory cortical circuitsCortical pyramidal neuronsD2 receptor antagonistGrowth factor receptor 1Spontaneous locomotor hyperactivityFibroblast growth factor receptor 1Factor receptor 1Inhibitory neuronal subtypesLocomotor hyperactivityDopamine agonistsCerebral cortexPyramidal neuronsBasal gangliaMotor hyperactivityReceptor antagonistInhibitory interneuronsTyrosine hydroxylaseCortical circuitsPsychiatric disordersLocomotor responseNeuronal subtypesReceptor 1Mutant miceDopamine transporterSpatial learning
2006
Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review
Rasmusson AM, Picciotto MR, Krishnan-Sarin S. Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review. Journal Of Psychopharmacology 2006, 20: 693-707. PMID: 16401662, DOI: 10.1177/0269881106060193.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderMental health disordersTobacco dependenceSmoking statusHealth disordersStress disorderMental health care providersHealth care providersNovel treatment interventionsClinical research studiesEffective clinical researchPublic health officialsNeurobiological mediatorsPathogenetic mechanismsSmoking ratesTranslational neuroscience perspectiveCare providersConcerned family membersEpidemiological studiesGeneral populationPsychiatric disordersTreatment interventionsClinical researchCritical covariatesHealth officialsGalanin: a novel therapeutic target for depression, anxiety disorders and drug addiction?
Holmes A, Picciotto MR. Galanin: a novel therapeutic target for depression, anxiety disorders and drug addiction? CNS & Neurological Disorders - Drug Targets 2006, 5: 225-32. PMID: 16611095, DOI: 10.2174/187152706776359600.Peer-Reviewed Original ResearchConceptsStress-related neural pathwaysBrain stress pathwaysSerotonin-producing neuronsDistribution of galaninDepression-related behaviorsDorsal raphe nucleusExpression of galaninAdministration of galaninNovel therapeutic targetDrug addictionPotential roleAnxiety-like responsesGalanin agonistsGalanin systemRaphe nucleusDopamine neuronsOpiate withdrawalLocus coeruleusNeuronal typesRodent modelsCurrent evidenceGalaninPsychiatric disordersTherapeutic targetOpiate reinforcement