2000
Nicotinic Receptors in the Brain: Links between Molecular Biology and Behavior
Picciotto M, Caldarone B, King S, Zachariou V. Nicotinic Receptors in the Brain: Links between Molecular Biology and Behavior. Neuropsychopharmacology 2000, 22: 451-465. PMID: 10731620, DOI: 10.1016/s0893-133x(99)00146-3.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNicotinic receptorsIndividual subunitsNicotinic receptor subtypesNicotinic receptor agonistsMolecular biologyNicotinic acetylcholine receptorsAcetylcholine receptor subunitsPain sensitivityReceptor agonistReceptor subtypesAnimal studiesNicotinic subunitsAcetylcholine receptorsAddictive propertiesMolecular cloningMolecular dataReceptor subunitsBehavioral effectsNicotineSubunit combinationsReceptorsNative receptorSubunitsSubunit compositionSubsequent studies
1999
Use of knock-out mice to determine the molecular basis for the actions of nicotine
Picciotto M, Zoli M, Changeux J. Use of knock-out mice to determine the molecular basis for the actions of nicotine. Nicotine & Tobacco Research 1999, 1: s121-s125. PMID: 11768168, DOI: 10.1080/14622299050011931.Peer-Reviewed Original ResearchConceptsElectrophysiological propertiesBehavioral effectsSubunit combinationsAction of nicotineDifferent neurotransmitter systemsEffects of nicotineMesolimbic dopamine systemIndividual receptor subtypesNicotinic acetylcholine receptorsBinding of nicotinePossible subunit combinationsDifferent subunit combinationsNicotine effectsNicotine receptorsNicotine reinforcementReceptor subtypesDopamine levelsNeurotransmitter systemsDopamine systemNicotinic subunitsAcetylcholine receptorsAddictive propertiesNicotineMiceBeta2 subunit
1995
Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain
Picciotto M, Zoli M, Léna C, Bessis A, Lallemand Y, LeNovère N, Vincent P, Pich E, Brûlet P, Changeux J. Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brain. Nature 1995, 374: 65-67. PMID: 7870173, DOI: 10.1038/374065a0.Peer-Reviewed Original ResearchConceptsHigh-affinity nicotine receptorsNeuronal nicotinic acetylcholine receptorsBrains of miceΒ2-/- miceNicotinic acetylcholine receptorsThalamic neuronsNicotine applicationFunctional nAChRsNicotine receptorsBrain slicesNicotinic subunitsAbnormal avoidanceAcetylcholine receptorsAspects of behaviorHigh-affinity binding sitesMutant miceElectrophysiological recordingsPassive avoidanceAssociative memoryMiceNicotineNeuronal nicotinic subunitsNon-mutant siblingsBrainReceptors