2018
Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus
Calarco CA, Li Z, Taylor SR, Lee S, Zhou W, Friedman JM, Mineur YS, Gotti C, Picciotto MR. Molecular and cellular characterization of nicotinic acetylcholine receptor subtypes in the arcuate nucleus of the mouse hypothalamus. European Journal Of Neuroscience 2018, 48: 1600-1619. PMID: 29791746, PMCID: PMC6251769, DOI: 10.1111/ejn.13966.Peer-Reviewed Original ResearchPOMC cellsArcuate nucleusFood intakeOrexigenic agouti-related peptideNicotinic acetylcholine receptor subtypesAnorexigenic pro-opiomelanocortin (POMC) neuronsDecrease food intakePro-opiomelanocortin (POMC) neuronsAcetylcholine receptor subtypesMRNA levelsAgouti-related peptideNicotinic agonist cytisineNicotinic acetylcholine receptorsSubunit mRNA levelsNeuronal cell typesAnorexigenic neuronsNicotinic regulationNicotinic modulationSmall hairpin RNAHypothalamic regionsReal-time PCRReceptor subtypesAgonist cytisineΑ7 subunitAcetylcholine receptors
2010
The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative‐Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice
Kamens HM, Andersen J, Picciotto MR. The Nicotinic Acetylcholine Receptor Partial Agonist Varenicline Increases the Ataxic and Sedative‐Hypnotic Effects of Acute Ethanol Administration in C57BL/6J Mice. Alcohol Clinical And Experimental Research 2010, 34: 2053-2060. PMID: 20946306, PMCID: PMC2988947, DOI: 10.1111/j.1530-0277.2010.01301.x.Peer-Reviewed Original ResearchConceptsSedative-hypnotic effectsBaseline locomotor activityFixed-speed rotarodAlcohol abuseEthanol consumptionNicotinic acetylcholine receptor partial agonist vareniclineLocomotor activityEthanol-induced motor incoordinationAbility of vareniclineAcute ethanol injectionDuration of LORRLocomotor activity chambersEffects of vareniclineAcute ethanol administrationNew pharmacologic strategiesDowel testDuration of lossPartial agonist vareniclineEthanol-induced ataxiaBalance beamNicotinic modulationPharmacologic strategiesMotor incoordinationEthanol administrationSedative effects
2000
Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization.
George TP, Verrico CD, Picciotto MR, Roth RH. Nicotinic modulation of mesoprefrontal dopamine neurons: pharmacologic and neuroanatomic characterization. Journal Of Pharmacology And Experimental Therapeutics 2000, 295: 58-66. PMID: 10991961.Peer-Reviewed Original ResearchConceptsMesoprefrontal DA neuronsDA neuronsLocal infusionNicotinic acetylcholine receptor stimulationMesoprefrontal dopamine neuronsMesoprefrontal dopamine systemEndogenous opioid peptidesVentral tegmental areaHigh comorbid ratesNicotine-pretreated ratsMedial prefrontal cortexDA metabolismNicotinic modulationCortical dysfunctionNicotine administrationCigarette smokingSite of actionStress-induced statesNicotine pretreatmentDA dysregulationDopamine neuronsSystemic administrationTegmental areaDA dysfunctionCognitive dysfunction