2012
Imaging Changes in Synaptic Acetylcholine Availability in Living Human Subjects
Esterlis I, Hannestad JO, Bois F, Sewell RA, Tyndale RF, Seibyl JP, Picciotto MR, Laruelle M, Carson RE, Cosgrove KP. Imaging Changes in Synaptic Acetylcholine Availability in Living Human Subjects. Journal Of Nuclear Medicine 2012, 54: 78-82. PMID: 23160789, PMCID: PMC3703589, DOI: 10.2967/jnumed.112.111922.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptor availabilityEndogenous neurotransmitter acetylcholineNicotinic acetylcholine receptorsPhysostigmine administrationAcetylcholine availabilityExtracellular acetylcholineBaseline scanHealthy subjectsReceptor availabilityExtracellular levelsAcetylcholine receptorsMolecular neuroimagingSPECT studiesAcetylcholineNonhuman primatesTissue concentrationsNeurotransmitter acetylcholineHuman subjectsSignificant reductionAdditional scansScansParent concentrationsSubjectsVivo estimationIA
2009
Biological Basis for the Co-morbidity Between Smoking and Mood Disorders
Mineur YS, Picciotto MR. Biological Basis for the Co-morbidity Between Smoking and Mood Disorders. Journal Of Dual Diagnosis 2009, 5: 122-130. PMID: 20046987, PMCID: PMC2707026, DOI: 10.1080/15504260902869964.Peer-Reviewed Original ResearchNicotinic antagonistsCholinergic activityDepressed patientsMood disordersNicotinic receptorsNicotine dependenceHigh-affinity nicotinic receptorsChronic nicotine useMajor preventable causeEpisodes of depressionPre-clinical studiesClassical antidepressantsAdjunct therapyPreventable causeDepressive disorderMajor depressionUnderlying biological factorsDepressive symptomsNicotine useSmokingDepressionAntidepressantsDisordersHuman subjectsPatients