1999
Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation
Lawson N, Zain M, Zibello T, Picciotto M, Nairn A, Berliner N. Modulation of a calcium/calmodulin-dependent protein kinase cascade by retinoic acid during neutrophil maturation. Experimental Hematology 1999, 27: 1682-1690. PMID: 10560916, DOI: 10.1016/s0301-472x(99)00108-3.Peer-Reviewed Original ResearchConceptsKinase cascadeCaM kinase cascadeNeutrophil maturationRetinoic acidDependent protein kinase kinase alphaWestern analysisProtein kinase cascadeSpecific gene expressionImmediate early fashionNeutrophil-specific gene expressionTrans retinoic acidNeutrophil progenitor cellsRetinoic acid receptorsNeutrophil functionUninduced cellsGene expressionKinase alphaMyeloid cellsVitamin AAcid receptorsRetinoid signalingCell typesEffect of calciumProgenitor cellsProtein levelsExpression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine
Kelz M, Chen J, Carlezon W, Whisler K, Gilden L, Beckmann A, Steffen C, Zhang Y, Marotti L, Self D, Tkatch T, Baranauskas G, Surmeier D, Neve R, Duman R, Picciotto M, Nestler E. Expression of the transcription factor ΔFosB in the brain controls sensitivity to cocaine. Nature 1999, 401: 272-276. PMID: 10499584, DOI: 10.1038/45790.Peer-Reviewed Original ResearchConceptsNucleus accumbensGlutamate receptor subunit GluR2Locomotor-activating effectsFos family transcription factorsTranscription factor ΔFosBDrugs of abuseΔFosB expressionAcute exposureTransgenic miceChronic exposureSubunit GluR2ΔFosBCocaine addictionAccumbensCocainePersistent expressionTranscription factorsSustained accumulationBrainExposureStable isoformSubset of nucleiExpressionGene expressionMorphine
1994
Calcium/calmodulin-dependent protein kinases.
Nairn AC, Picciotto MR. Calcium/calmodulin-dependent protein kinases. Seminars In Cancer Biology 1994, 5: 295-303. PMID: 7803766.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCalcium-Calmodulin-Dependent Protein Kinase Type 1Calcium-Calmodulin-Dependent Protein Kinase Type 2Calcium-Calmodulin-Dependent Protein Kinase Type 4Calcium-Calmodulin-Dependent Protein KinasesElongation Factor 2 KinaseHumansMolecular Sequence DataMyosin-Light-Chain KinasePhosphorylationConceptsProtein kinaseSecond messenger-regulated protein kinasesCaM-dependent protein kinaseEssential intracellular second messengerEF-2 kinaseCaM kinase ICaM kinase IVCaM kinase IIIntracellular second messengerMyosin light chain kinaseEukaryotic systemsProtein phosphorylationKinase ILight chain kinaseKinase IIPhosphorylase kinaseGene expressionKinase IVSecond messengerKinaseChain kinaseImportant familyCell proliferationNeurotransmitter releaseRegulation