2013
Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography
Hannestad JO, Cosgrove KP, DellaGioia NF, Perkins E, Bois F, Bhagwagar Z, Seibyl JP, McClure-Begley TD, Picciotto MR, Esterlis I. Changes in the Cholinergic System between Bipolar Depression and Euthymia as Measured with [123I]5IA Single Photon Emission Computed Tomography. Biological Psychiatry 2013, 74: 768-776. PMID: 23773793, PMCID: PMC3805761, DOI: 10.1016/j.biopsych.2013.04.004.Peer-Reviewed Original ResearchConceptsBipolar depressionControl subjectsCholinergic systemSingle photon emissionBipolar disorderAge-matched control subjectsEndogenous acetylcholine levelsNew treatment targetsNicotinic acetylcholine receptorsPhoton emissionLow receptor numbersClinical characteristicsEndogenous acetylcholineDepressive episodeAcetylcholine levelsTomography scanMajor depressionReceptor numberTemporal cortexNAChR numbersTreatment targetsAcetylcholine receptorsControl groupBrain regionsLower β2
2012
Persistent β2*-Nicotinic Acetylcholinergic Receptor Dysfunction in Major Depressive Disorder
Saricicek A, Esterlis I, Maloney KH, Mineur YS, Ruf BM, Muralidharan A, Chen JI, Cosgrove KP, Kerestes R, Ghose S, Tamminga CA, Pittman B, Bois F, Tamagnan G, Seibyl J, Picciotto MR, Staley JK, Bhagwagar Z. Persistent β2*-Nicotinic Acetylcholinergic Receptor Dysfunction in Major Depressive Disorder. American Journal Of Psychiatry 2012, 169: 851-859. PMID: 22772158, PMCID: PMC3494404, DOI: 10.1176/appi.ajp.2012.11101546.Peer-Reviewed Original ResearchConceptsMajor depressive disorderNAChR availabilityDepressed patientsComparison subjectsDepressed subjectsDepressive disorderReceptor availabilityAge-matched comparison subjectsLower receptor availabilityEarly-onset depressionPostmortem brain samplesDopamine receptor availabilityNicotinic acetylcholine receptorsSingle photon emissionPost-mortem samplesEndogenous acetylcholinePrefrontal cortex samplesReceptor dysfunctionDepressive episodePostmortem studiesTrauma ScoreIll subjectsSPECT ligandHealthy subjectsSPECT scans
2011
Nociceptive thresholds are controlled through spinal β2-subunit-containing nicotinic acetylcholine receptors
Yalcin I, Charlet A, Cordero-Erausquin M, Tessier L, Picciotto MR, Schlichter R, Poisbeau P, Freund-Mercier M, Barrot M. Nociceptive thresholds are controlled through spinal β2-subunit-containing nicotinic acetylcholine receptors. Pain 2011, 152: 2131-2137. PMID: 21794985, DOI: 10.1016/j.pain.2011.05.022.Peer-Reviewed Original ResearchConceptsNociceptive thresholdKO miceNicotinic acetylcholine receptorsNociceptive informationMechanical thresholdHigh-frequency transcutaneous electrical nerve stimulationAcetylcholine receptorsTranscutaneous electrical nerve stimulationHigh-frequency TENSInhibitory controlReceptor antagonist bicucullineElectrical nerve stimulationC-fiber stimulationTonic inhibitory controlMechanical nociceptive thresholdThermal nociceptive thresholdInhibitory transmissionAntagonist bicucullineGABAergic controlGABAergic transmissionEndogenous acetylcholineGABAergic inhibitionNerve stimulationNociceptive processingNociceptive responses
2004
Alteration of hippocampal cell proliferation in mice lacking the β2 subunit of the neuronal nicotinic acetylcholine receptor
Harrist A, Beech RD, King SL, Zanardi A, Cleary MA, Caldarone BJ, Eisch A, Zoli M, Picciotto MR. Alteration of hippocampal cell proliferation in mice lacking the β2 subunit of the neuronal nicotinic acetylcholine receptor. Synapse 2004, 54: 200-206. PMID: 15472930, DOI: 10.1002/syn.20081.Peer-Reviewed Original ResearchConceptsNicotinic acetylcholine receptorsHippocampal cell proliferationAcetylcholine receptorsCell proliferationNeuronal nicotinic acetylcholine receptorsNeurotrophic factor BDNFAdult hippocampal neurogenesisHippocampus of miceAge-matched controlsGranule cell layerCellular proliferationPlasma corticosterone levelsHippocampal-dependent tasksGranule cell proliferationHippocampal proliferationHippocampal neurogenesisEndogenous acetylcholineAge-related declineDentate gyrusNeuronal survivalAbnormal myelinationCorticosterone levelsNormal agingYoung adultsApoptotic cell death