2019
Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine
Lee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR. Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine. Genes Brain & Behavior 2019, 19: e12601. PMID: 31364813, PMCID: PMC8045136, DOI: 10.1111/gbb.12601.Peer-Reviewed Original ResearchConceptsStress-induced reinstatementEffects of guanfacinePlace preferenceFemale miceInfralimbic cortexArc immunoreactivityΑ2-adrenergic receptor agonistAnterior insulaNeurobiological mechanismsLateral central amygdalaNovel treatment optionsChamber preferencePlace preference acquisitionSex-dependent changesStress-induced relapseDose-response patternNucleus accumbens coreNicotine-dependent behaviorsSmoking occursTreatment optionsNicotine rewardReceptor agonistCentral amygdalaNeuronal activationPreclinical studies
2014
GABAergic and glutamatergic efferents of the mouse ventral tegmental area
Taylor SR, Badurek S, Dileone RJ, Nashmi R, Minichiello L, Picciotto MR. GABAergic and glutamatergic efferents of the mouse ventral tegmental area. The Journal Of Comparative Neurology 2014, 522: 3308-3334. PMID: 24715505, PMCID: PMC4107038, DOI: 10.1002/cne.23603.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell CountCholine O-AcetyltransferaseDependovirusEfferent PathwaysGABAergic NeuronsGlutamate DecarboxylaseGlutamatesLuminescent ProteinsMiceMice, Inbred C57BLMice, TransgenicStilbamidinesSubstance PTyrosine 3-MonooxygenaseVentral Tegmental AreaVesicular Glutamate Transport Protein 2Vesicular Inhibitory Amino Acid Transport ProteinsConceptsVentral tegmental areaGABA neuronsVTA GABATegmental areaMouse ventral tegmental areaGABA projection neuronsVTA GABAergic neuronsVTA GABA neuronsMagnocellular preoptic nucleusDeep mesencephalic nucleusLocal inhibitory connectionsPrefrontal cortical regionsDrugs of abuseGlutamatergic efferentsSpecific anterogradeBrainstem targetsDorsal rapheNeurons projectGABAergic markersGABAergic neuronsRetrograde tracingProjection neuronsLateral hypothalamusMesencephalic nucleusCentral amygdala